TRIM39 and EPHB6

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM39	EPHB6
Description		tripartite motif containing 39	EPH receptor B6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Extracellular Region Cytosol Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection Receptor Complex
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Ephrin Receptor Activity Transmembrane-ephrin Receptor Activity ATP Binding Signaling Receptor Activity
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Multicellular Organism Development Axon Guidance Peptidyl-tyrosine Phosphorylation Central Nervous System Projection Neuron Axonogenesis Positive Regulation Of Kinase Activity Ephrin Receptor Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs			Fostamatinib
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Alcoholic chronic pancreatitis ( 28754779) Blood protein levels ( 30072576 29875488) Cancer ( 29299148)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	27 interacting genes: AFDN ASB12 CBL CRK CRKL DDIT4L DUSP18 DUSP19 EFNB2 EPHB1 ERBB2 GRB2 HDHD2 INCA1 MSX2 MTARC1 NIF3L1 NOTCH2NLA POU6F2 PRMT5 REL SAT1 STYX TCF4 TEKT5 TRIB3 TRIM39
Entrez ID		56658	2051
HPRD ID		09298	04133
Ensembl ID		ENSG00000204599	ENSG00000106123
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	F8WCM8 J3KQU5 O15197
PDB IDs		2DID 2DIF 2ECJ
Enriched GO Terms of Interacting Partners?
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