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TRIM39 and UBE2V1
Data Source:
BioGRID
(two hybrid)
TRIM39
UBE2V1
Description
tripartite motif containing 39
ubiquitin conjugating enzyme E2 V1
Image
GO Annotations
Cellular Component
Nucleus
Cytoplasm
Mitochondrion
Cytosol
Ubiquitin Ligase Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Ubiquitin Conjugating Enzyme Complex
Protein-containing Complex
UBC13-UEV1A Complex
Extracellular Exosome
Molecular Function
Protein Binding
Zinc Ion Binding
Identical Protein Binding
Ubiquitin Protein Ligase Activity
Protein Binding
Biological Process
Apoptotic Process
Mitotic G2 DNA Damage Checkpoint
Regulation Of Gene Expression
Protein Ubiquitination
Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Innate Immune Response
Protein Stabilization
Regulation Of Cell Cycle G1/S Phase Transition
Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Apoptotic Signaling Pathway
Activation Of MAPK Activity
Protein Polyubiquitination
Regulation Of DNA Repair
Postreplication Repair
Regulation Of Transcription, DNA-templated
JNK Cascade
Cell Differentiation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of NF-kappaB Transcription Factor Activity
Nucleotide-binding Oligomerization Domain Containing Signaling Pathway
Interleukin-1-mediated Signaling Pathway
Protein K63-linked Ubiquitination
Pathways
Antigen processing: Ubiquitination & Proteasome degradation
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
CLEC7A (Dectin-1) signaling
Interleukin-1 signaling
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
Aggrephagy
Aggrephagy
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Blood protein levels (
28240269
)
Cutaneous lupus erythematosus (
25827949
)
Neuroticism (
29255261
)
Interacting Genes
61 interacting genes:
APP
CACTIN
CCNC
DCUN1D1
DCX
DIP2A
EIF4A2
EPHB6
GAMT
HINFP
KDM1A
LMNA
LNX1
LXN
MED18
MNAT1
MTURN
OTUB2
OTUD6A
PDLIM5
PLCD4
POLI
PRPF3
PSMA6
PSMB1
PSMD9
RAD23A
RECK
RNF166
SMCO3
TP53
TRIM17
TRIM21
TRIM8
TTC32
UBAC1
UBC
UBE2D1
UBE2D2
UBE2D3
UBE2D4
UBE2E1
UBE2E2
UBE2E3
UBE2K
UBE2L3
UBE2N
UBE2V1
UBE2W
UBL5
UBTD1
UBTD2
UBXN1
UBXN6
UBXN7
USP2
USP39
USP5
WDFY3
ZKSCAN4
ZNF26
47 interacting genes:
ARIH2
BIRC2
BIRC3
BIRC8
CTAG1A
CTAG1B
DAZAP2
DTX3
DZIP3
FAM168A
KITLG
MAP3K1
MID1
MKRN3
PELI1
PELI3
PRKN
PSMD14
RC3H1
RC3H2
RNF10
RNF111
RNF14
RNF144A
RNF185
RNF2
RNF5
SHISA4
SMURF1
STUB1
SUMO4
TRAF2
TRAF3IP2
TRAF6
TRIM25
TRIM32
TRIM39
TRIM5
TRIM8
UBC
UBE2N
UBOX5
UBQLN1
UBQLN2
XBP1
XIAP
ZNRF1
Entrez ID
56658
7335
HPRD ID
09298
04294
Ensembl ID
ENSG00000204599
ENSG00000244687
Uniprot IDs
A0A024RCP5
A0A024RCR1
Q9HCM9
G3V2F7
Q13404
PDB IDs
2DID
2DIF
2ECJ
2A4D
2C2V
2HLW
6D6I
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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