TRIM39 and UBXN6

Data Source:
BioGRID (two hybrid)

		TRIM39	UBXN6
Description		tripartite motif containing 39	UBX domain protein 6
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Nucleus Cytoplasm Lysosomal Membrane Endosome Microtubule Organizing Center Cytosol Extrinsic Component Of Membrane Early Endosome Membrane Late Endosome Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	Protein Binding Zinc Ion Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Apoptotic Process Mitotic G2 DNA Damage Checkpoint Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Protein Stabilization Regulation Of Cell Cycle G1/S Phase Transition Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Signaling Pathway	Macroautophagy Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway ERAD Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Cutaneous lupus erythematosus ( 25827949) Neuroticism ( 29255261)	Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Multiple sclerosis ( 31604244) Red blood cell count ( 32888494)
Interacting Genes		61 interacting genes: APP CACTIN CCNC DCUN1D1 DCX DIP2A EIF4A2 EPHB6 GAMT HINFP KDM1A LMNA LNX1 LXN MED18 MNAT1 MTURN OTUB2 OTUD6A PDLIM5 PLCD4 POLI PRPF3 PSMA6 PSMB1 PSMD9 RAD23A RECK RNF166 SMCO3 TP53 TRIM17 TRIM21 TRIM8 TTC32 UBAC1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2K UBE2L3 UBE2N UBE2V1 UBE2W UBL5 UBTD1 UBTD2 UBXN1 UBXN6 UBXN7 USP2 USP39 USP5 WDFY3 ZKSCAN4 ZNF26	20 interacting genes: APP DAZAP2 DERL1 FAM168A GSK3B MAGEA4 MCL1 NLGN3 PLEKHB2 SMURF1 SUSD6 SVIP TRIM39 UBC UBXN10 UBXN2A UBXN2B UFD1 VCP YOD1
Entrez ID		56658	80700
HPRD ID		09298	18253
Ensembl ID		ENSG00000204599	ENSG00000167671
Uniprot IDs		A0A024RCP5 A0A024RCR1 Q9HCM9	Q9BZV1
PDB IDs		2DID 2DIF 2ECJ	6SAP
Enriched GO Terms of Interacting Partners?
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