PROP1 and METTL15

Data Source:
BioGRID (two hybrid)

		PROP1	METTL15
Description		PROP paired-like homeobox 1	methyltransferase like 15
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex	Mitochondrial Matrix
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Sequence-specific Double-stranded DNA Binding	RRNA (cytosine-N4-)-methyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Pituitary Gland Development	RRNA Base Methylation
Pathways
Drugs
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS			Adventurousness ( 30643258) Body size at age 10 ( 32376654) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Childhood body mass index ( 33045005) Chronotype ( 30696823) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 31959993) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes (adjusted for BMI) ( 30297969)
Interacting Genes		54 interacting genes: ABHD11 ARSA BATF2 C11orf1 C19orf54 C1orf94 C6orf15 C9orf24 COX6B2 CRYBA1 CYSRT1 DAZAP2 EFEMP2 FAM166A FAM168A HDHD3 HESX1 HNRNPF HOXA1 INTS11 KHDC1 KRTAP13-1 KRTAP19-1 KRTAP19-6 KRTAP19-7 KRTAP6-3 KRTAP8-1 MAGED1 METTL15 METTL27 NR1D2 OLIG3 OXER1 P4HA3 PITX2 PLEKHB2 POU6F2 PSMB11 PSMB4 RNF144B RNF4 SMUG1 SUMO1 TBX22 TEKT4 TEKT5 TENT5B TINAGL1 TLE5 TMEM42 TRIM42 UBE2I UFSP1 ZNF503	14 interacting genes: CIDEC CSTF2 FANCL GLYCTK HOXC8 MAPKBP1 MSRB3 NEK6 PEF1 PROP1 SPAG8 TRIP13 USHBP1 VAC14
Entrez ID		5626	196074
HPRD ID		03325	08750
Ensembl ID		ENSG00000175325	ENSG00000169519
Uniprot IDs		A0A0G2JQ02 O75360	A6NJ78
PDB IDs
Enriched GO Terms of Interacting Partners?
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