METTL15 and PEF1

Data Source:
BioGRID (two hybrid)

		METTL15	PEF1
Description		methyltransferase like 15	penta-EF-hand domain containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix	Golgi Membrane Cytoplasm Endoplasmic Reticulum COPII Vesicle Coat Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome
	Molecular Function	RRNA (cytosine-N4-)-methyltransferase Activity	RNA Binding Calcium Ion Binding Protein Binding Identical Protein Binding Protein Heterodimerization Activity Protein Dimerization Activity Calcium-dependent Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	RRNA Base Methylation	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination COPII Vesicle Coating Response To Calcium Ion Positive Regulation Of Protein Monoubiquitination
Pathways
Drugs			Calcium citrate Calcium Phosphate Calcium phosphate dihydrate
Diseases
GWAS		Adventurousness ( 30643258) Body size at age 10 ( 32376654) Childhood ALL/LBL (acute lymphoblastic leukemia/lymphoblastic lymphoma) treatment-related venous thromboembolism ( 32438682) Childhood body mass index ( 33045005) Chronotype ( 30696823) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Hip circumference adjusted for BMI ( 28552196) Intraocular pressure ( 31959993) Number of sexual partners ( 30643258) Obesity-related traits ( 23251661) Refractive error ( 32231278) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 27841878) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Type 2 diabetes (adjusted for BMI) ( 30297969)	Asthma ( 31959851) Body mass index ( 26426971) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Severe aortic features in Marfan syndrome ( 30087447)
Interacting Genes		14 interacting genes: CIDEC CSTF2 FANCL GLYCTK HOXC8 MAPKBP1 MSRB3 NEK6 PEF1 PROP1 SPAG8 TRIP13 USHBP1 VAC14	40 interacting genes: AKAP8L ALG2 ANKRD10 BAG4 BPIFA1 C11orf1 CALCOCO2 CEP55 CTAG1A CTAG1B CUL3 DAZAP2 DMRTB1 EIF4G1 EWSR1 FAM168A FOXR2 HEMK1 HGS HYDIN INCA1 KLHL12 KRTAP12-1 KRTAP15-1 KRTAP19-1 MED25 METTL15 NR0B2 PDCD6 SEC24A SEC31A SMUG1 SOHLH1 SPAG8 SPG21 STH TFG VPS37C WWOX ZIC1
Entrez ID		196074	553115
HPRD ID		08750	10143
Ensembl ID		ENSG00000169519	ENSG00000162517
Uniprot IDs		A6NJ78	A0A384MQX5 Q9UBV8
PDB IDs
Enriched GO Terms of Interacting Partners?
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