MINDY1 and LSM8

Data Source:
HPRD (two hybrid)

		MINDY1	LSM8
Description		MINDY lysine 48 deubiquitinase 1	LSM8 homolog, U6 small nuclear RNA associated
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Nuclear Body Cell Periphery	Nucleus Nucleoplasm U6 SnRNP U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Lsm2-8 Complex
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Cysteine-type Carboxypeptidase Activity K48-linked Polyubiquitin Modification-dependent Protein Binding Lys48-specific Deubiquitinase Activity	RNA Binding Protein Binding U6 SnRNA Binding
	Biological Process	Biological_process Protein Phosphopantetheinylation Protein K48-linked Deubiquitination	MRNA Splicing, Via Spliceosome RNA Metabolic Process
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS			Anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Anti-thyroid peroxidase (TPOAb) and anti-thyroglobulin (TgAb) levels in Hashimoto's thyroiditis ( 30926877) Glaucoma (primary open-angle) ( 29891935) Intraocular pressure ( 29617998) Plasma anti-thyroid peroxidase levels ( 29678681) Positive urgency ( 30718321) Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Triglyceride levels ( 30108155)
Interacting Genes		4 interacting genes: DAZAP2 GMCL1 LSM8 UBC	49 interacting genes: ARNT BCKDK COL23A1 DBF4 DCP1A DCP1B DPAGT1 ECHDC2 EFTUD2 EXOSC10 EXOSC6 FERMT3 GMPPA GTF2I HSPA9 IFNLR1 IGHMBP2 ISOC2 ITSN2 KCTD3 LSM2 LSM3 LSM5 LSM6 LSM7 MAPK8IP2 MGA MINDY1 MPRIP MRPL48 MTHFR NAGK NME4 PDCD2 PGD PHF11 RBM5 RPL24 RSC1A1 RSL24D1 SEPTIN10 SEPTIN5 SMU1 SNRNP200 SNRPB SNRPD1 TALDO1 THUMPD3 UPF1
Entrez ID		55793	51691
HPRD ID		07746	06288
Ensembl ID		ENSG00000143409	ENSG00000128534
Uniprot IDs		D3DV11 Q8N5J2	A4D0W0 O95777
PDB IDs		5JKN 5JQS 5MN9	3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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