ARFGAP1 and RAB23

Data Source:
BioGRID (two hybrid)

		ARFGAP1	RAB23
Description		ADP ribosylation factor GTPase activating protein 1	RAB23, member RAS oncogene family
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Synapse	Cytoplasm Autophagosome Centrosome Cytosol Plasma Membrane Endosome Membrane Endomembrane System Cell Junction Phagocytic Vesicle Membrane Phagocytic Vesicle
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	GTPase Activity Protein Binding GTP Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Autophagosome Assembly Intracellular Protein Transport Cellular Defense Response Negative Regulation Of Protein Import Into Nucleus GTP Metabolic Process Cilium Assembly Craniofacial Suture Morphogenesis
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	RAB geranylgeranylation
Drugs
Diseases			Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
GWAS			Coronary artery disease ( 30104761) Systemic lupus erythematosus ( 28714469)
Interacting Genes		34 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	2 interacting genes: ARFGAP1 CREB3
Entrez ID		55738	51715
HPRD ID		06443	05850
Ensembl ID		ENSG00000101199	ENSG00000112210
Uniprot IDs		Q53F62 Q8N6T3	A0A024RD41 Q9ULC3
PDB IDs		3DWD 3O47
Enriched GO Terms of Interacting Partners?
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