ARFGAP1 and COPA

Data Source:
HPRD (in vitro, in vivo)

		ARFGAP1	COPA
Description		ADP ribosylation factor GTPase activating protein 1	COPI coat complex subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Cytosol Synapse	Golgi Membrane Extracellular Space Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane COPI Vesicle Coat Transport Vesicle Growth Cone Extracellular Exosome
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Hormone Activity Structural Molecule Activity Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity	Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Intra-Golgi Vesicle-mediated Transport Signal Transduction Pancreatic Juice Secretion
Pathways		XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis	COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases
GWAS			Breast size ( 27182965)
Interacting Genes		34 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23	18 interacting genes: ARCN1 ARFGAP1 CDC42 COPB2 COPE DUX4 MTNR1B PDGFRB PTEN SACM1L SCYL1 SLC25A11 STX8 SUMO2 TMED10 TMED2 WBP1 WBP2
Entrez ID		55738	1314
HPRD ID		06443	03564
Ensembl ID		ENSG00000101199	ENSG00000122218
Uniprot IDs		Q53F62 Q8N6T3	P53621
PDB IDs		3DWD 3O47	6PBG 6TZT 6U3V
Enriched GO Terms of Interacting Partners?
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