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FAM90A1 and PSME3
Data Source:
BioGRID
(two hybrid)
FAM90A1
PSME3
Description
family with sequence similarity 90 member A1
proteasome activator subunit 3
Image
No pdb structure
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Proteasome Activator Complex
Membrane
Molecular Function
Protein Binding
P53 Binding
Protein Binding
Identical Protein Binding
Endopeptidase Activator Activity
MDM2/MDM4 Family Protein Binding
Biological Process
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Regulation Of Cellular Amino Acid Metabolic Process
Apoptotic Process
Cell Cycle
Positive Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Regulation Of G1/S Transition Of Mitotic Cell Cycle
Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Gut microbiota (functional units) (
27694959
)
Interacting Genes
162 interacting genes:
ABI2
ACTN3
AKAP9
AMOTL2
ANKRD23
ANKRD29
AP2M1
APP
ARHGEF9
ARRDC3
BANP
BCAR1
BEGAIN
BHLHB9
BLZF1
CADPS
CALCOCO2
CARD9
CCDC13
CCDC57
CCN3
CCNC
CCNL2
CDR2
CEP55
CEP70
CEP72
CEP76
CHRDL2
COG6
CYSRT1
DTX3
DVL2
DVL3
EFEMP2
ENKD1
EXOSC8
FAM228A
FHL3
FLACC1
FLOT1
FOSB
FSD2
FXR1
FXR2
FYN
GABPB1
GCSAML
GNPTAB
GOLGA2
GOPC
GPSM1
GRIPAP1
HAND2
HMBOX1
HOMER3
HOMEZ
HOOK2
HSF2BP
ISY1
KANK2
KASH5
KIFC3
KLHL12
KPNA3
KPNA6
KRT31
KRT34
KRT38
KRT40
KRTAP1-1
KRTAP10-8
LDOC1
LHX6
LIMS1
LMO2
LNX1
LRP2BP
LRRK2
LZTS1
LZTS2
MAD1L1
MDFI
MEIS3
MID2
MIPOL1
MLH1
MORN3
MSS51
MTUS2
MYOG
NBPF19
NDUFB7
NOTCH2NLA
NUDT21
OVOL1
PBX1
PBX2
PDLIM7
PFDN5
PICK1
PIH1D1
PLAGL2
POF1B
PPARA
PPP1R13B
PRDM6
PRKAR1B
PRR23B
PSME3
PSTPIP1
RAB11FIP2
RABEP1
RBM48
REL
RHOH
RINT1
ROPN1
RPRD1A
SH2B2
SIAH1
SMAD3
SMARCB1
SNW1
SPRED1
SRPK2
STAC3
STMN2
STX11
TAX1BP1
TEPSIN
TFIP11
TLE5
TMCC2
TRAF2
TRAF4
TRIB3
TRIM23
TRIM27
TRIM42
TRIM54
TRIM55
TRIM69
TRIM9
TRIML2
VRTN
VWC2
ZBTB14
ZBTB16
ZBTB7B
ZBTB8A
ZC2HC1C
ZMYND12
ZNF143
ZNF212
ZNF343
ZNF526
ZNF581
ZNF655
ZNF688
ZNF76
ZWINT
64 interacting genes:
ABCF3
ADAP1
AICDA
ATN1
ATP5F1B
BBS2
CASP3
CASP6
CASP7
CDC25B
CDC42
CDR2L
CHEK2
COIL
CREBBP
DEPTOR
DIP2A
DMRT3
DTNBP1
DVL3
EAF1
EAF2
FAM90A1
FBXL12
FBXL19
FOXD4L1
FXR2
GPATCH2L
HSPA5
INPP5J
ITPKB
KANSL1
KBTBD7
KLF2
LNX1
MDM2
MEOX2
NCOA3
NTAQ1
NUDT18
PFDN5
PIAS1
PICK1
PRKAB2
PRR13
RDX
RNF111
RPH3AL
RPS27
SERF2
SIRT1
SMURF1
SPG7
TBP
TBXA2R
THAP10
TNFAIP8L1
TP53
TXN2
UBE2H
UBE2I
WDR25
YWHAQ
ZCCHC10
Entrez ID
55138
10197
HPRD ID
07672
05500
Ensembl ID
ENSG00000171847
ENSG00000131467
Uniprot IDs
Q86YD7
A0A024R203
B3KQ25
P61289
Q6MZZ1
V9HWJ8
PDB IDs
Enriched GO Terms of Interacting Partners
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