PPHLN1 and TGM2

Data Source:
HPRD (in vitro)

		PPHLN1	TGM2
Description		periphilin 1	transglutaminase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Chromosome Golgi Apparatus Cytosol	Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Protein Localization To Heterochromatin	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Phosphopantetheinylation Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation
Pathways
Drugs			Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: APP BCL2L1 BRCA1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 ITGB1BP2 MTUS2 NAGK PAXIP1 PPL SEPTIN8 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM	59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B
Entrez ID		51535	7052
HPRD ID		10488	01825
Ensembl ID		ENSG00000134283	ENSG00000198959
Uniprot IDs		Q8NEY8	B4DIT7 B4DTN7 P21980 V9HWG3
PDB IDs		6SWG	1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P
Enriched GO Terms of Interacting Partners?
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