TGM2 and EIF5A

Data Source:
HPRD (in vitro, in vivo)

		TGM2	EIF5A
Description		transglutaminase 2	eukaryotic translation initiation factor 5A
Image
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Nucleus Annulate Lamellae Nuclear Pore Cytoplasm Endoplasmic Reticulum Membrane Cytosol Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	RNA Binding Translation Elongation Factor Activity Protein Binding U6 SnRNA Binding Ribosome Binding Protein N-terminus Binding
	Biological Process	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Phosphopantetheinylation Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	MRNA Export From Nucleus Translational Elongation Protein Export From Nucleus Nucleocytoplasmic Transport Apoptotic Process Positive Regulation Of Cell Population Proliferation Positive Regulation Of Translational Elongation Positive Regulation Of Translational Termination
Pathways			Hypusine synthesis from eIF5A-lysine
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS			Venous thromboembolism ( 31420334)
Interacting Genes		59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B	17 interacting genes: CRX DHPS DOHH GSC2 LBX1 MEI4 MEOX2 PICK1 REL RPL5 SDCBP STUB1 SUMO2 TGM2 XPO1 XPO4 XRN2
Entrez ID		7052	1984
HPRD ID		01825	02555
Ensembl ID		ENSG00000198959	ENSG00000132507
Uniprot IDs		B4DIT7 B4DTN7 P21980 V9HWG3	P63241
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P	1FH4 3CPF 5DLQ
Enriched GO Terms of Interacting Partners?
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