TGM2 and SIPA1L2

Data Source:
BioGRID (two hybrid)

		TGM2	SIPA1L2
Description		transglutaminase 2	signal induced proliferation associated 1 like 2
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Cytosol Plasma Membrane Focal Adhesion Intrinsic Component Of Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome	Cellular_component Cytoplasm
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding GTP Binding Protein Domain Specific Binding Identical Protein Binding Metal Ion Binding	GTPase Activator Activity
	Biological Process	Blood Vessel Remodeling Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Protein Phosphopantetheinylation Negative Regulation Of Endoplasmic Reticulum Calcium Ion Concentration Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Cell Clearance Positive Regulation Of Cell Adhesion Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Mitochondrial Calcium Ion Concentration Branching Involved In Salivary Gland Morphogenesis Salivary Gland Cavitation	Biological_process Regulation Of Small GTPase Mediated Signal Transduction Activation Of GTPase Activity
Pathways
Drugs		Guanosine-5'-Diphosphate Hexylresorcinol
Diseases
GWAS			Body size at age 10 ( 32376654) Immunoglobulin A ( 20694011) Parkinson's disease ( 25064009 32201043 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Post-traumatic stress disorder ( 24677629) PR interval ( 32439900) Reduced foot dorsiflexion strength in Charcot-Marie-Tooth disease type 1A ( 30706531) Schizophrenia ( 30285260) Smooth-surface caries ( 24556642)
Interacting Genes		59 interacting genes: A2M ABCA1 ACTB ADAR ALDOA ANKRD28 ANXA1 APP ARNT ATF4 BNIP3 C3 CASP3 CBL CERT1 CSNK2A2 EIF5A FN1 FNTA GCGR GRN GSTP1 H2BC21 H2BC8 HNRNPF HNRNPUL1 HP HSPA1A HSPA1B HSPA8 HTT ITGB1 ITGB3 KPNA3 KPNA4 LACRT LTBP1 MAP3K12 PAK1 PINK1 PLCD1 PPHLN1 PXN RB1 RELA RHOA S100A7 SERPINF2 SERTAD1 SIPA1L2 SLC7A9 SMAD2 SMAD3 SPARC TAB2 TMEM176A TMSB4X TUBB ZNF512B	5 interacting genes: AP3M1 DDX6 ORC5 TCEANC TGM2
Entrez ID		7052	57568
HPRD ID		01825	15346
Ensembl ID		ENSG00000198959	ENSG00000116991
Uniprot IDs		B4DIT7 B4DTN7 P21980 V9HWG3	A0A6Q8PH54 Q9P2F8
PDB IDs		1FAU 1KV3 2Q3Z 3LY6 3S3J 3S3P 3S3S 4PYG 6A8P
Enriched GO Terms of Interacting Partners?
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