PPHLN1 and UFD1

Data Source:
BioGRID (two hybrid)

		PPHLN1	UFD1
Description		periphilin 1	ubiquitin recognition factor in ER associated degradation 1
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GO Annotations	Cellular Component	Nucleoplasm Chromosome Golgi Apparatus Cytosol	Nucleus Nucleoplasm Cytosol VCP-NPL4-UFD1 AAA ATPase Complex UFD1-NPL4 Complex
	Molecular Function	RNA Binding Protein Binding	Thiol-dependent Ubiquitin-specific Protease Activity Signaling Receptor Binding Protein Binding Polyubiquitin Modification-dependent Protein Binding K48-linked Polyubiquitin Modification-dependent Protein Binding Protein-containing Complex Binding ATPase Binding
	Biological Process	Keratinization Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly Protein Localization To Heterochromatin	Skeletal System Development Ubiquitin-dependent Protein Catabolic Process Protein Deubiquitination Protein Phosphopantetheinylation Ubiquitin-dependent ERAD Pathway Retrograde Protein Transport, ER To Cytosol Negative Regulation Of Type I Interferon Production Negative Regulation Of RIG-I Signaling Pathway Error-free Translesion Synthesis ER-associated Misfolded Protein Catabolic Process
Pathways			Translesion Synthesis by POLH Ub-specific processing proteases
Drugs
Diseases
GWAS		Body size at age 10 ( 32376654) Coronary artery disease ( 29212778) Diastolic blood pressure ( 30224653) Refractive error ( 32231278)
Interacting Genes		25 interacting genes: APP BCL2L1 BRCA1 CASP5 CCDC57 CDC37 CDK6 CLK1 FBXO7 ITGB1BP2 MTUS2 NAGK PAXIP1 PPL SEPTIN8 SNCAIP SQSTM1 SRPK2 TGM2 TOMM20 TOPBP1 TP53BP2 TSGA10 UFD1 VIM	23 interacting genes: A2M AMFR ANAPC2 CHMP2A F13A1 GZMK HSPB1 IGHM LRRK2 MAP3K1 MASP1 NGFR NPLOC4 NUB1 PIK3CA PPHLN1 SNX1 TAF1C TIAM2 TP53 UBC UBXN6 VCP
Entrez ID		51535	7353
HPRD ID		10488	06778
Ensembl ID		ENSG00000134283	ENSG00000070010
Uniprot IDs		Q8NEY8	Q541A5 Q92890
PDB IDs		6SWG	2YUJ 5B6C 5C1B
Enriched GO Terms of Interacting Partners?
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