KLF3 and LSM3

Data Source:
BioGRID (two hybrid)

		KLF3	LSM3
Description		Kruppel like factor 3	LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleoplasm	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Binding Protein Binding U6 SnRNA 3'-end Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Cellular Response To Peptide	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA
Pathways			mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Adult body size ( 32376654) Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31959851) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 23850713) Endometriosis or endometrial cancer (pleiotropy) ( 29608257) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Hand grip strength ( 29691431) Helicobacter pylori serologic status ( 23652523) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Mean platelet volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Subcortical volume (MOSTest) ( 32665545) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		14 interacting genes: CTBP1 CTBP2 DVL3 EHMT2 FHL3 KDM1A LHX6 LHX8 LSM3 OTX2 PIAS1 SUV39H2 TRAF2 UBE2I	48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1
Entrez ID		51274	27258
HPRD ID		13920	06283
Ensembl ID		ENSG00000109787	ENSG00000170860
Uniprot IDs		P57682	P62310
PDB IDs			3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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