LSM3 and EIF4EBP2

Data Source:
BioGRID (two hybrid)

		LSM3	EIF4EBP2
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	eukaryotic translation initiation factor 4E binding protein 2
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GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	Cytoplasm Postsynapse
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	Protein Binding Eukaryotic Initiation Factor 4E Binding Translation Repressor Activity
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA	Translation Memory Insulin Receptor Signaling Pathway CAMP-mediated Signaling TOR Signaling Social Behavior Negative Regulation Of Translational Initiation Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)
Interacting Genes		48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1	6 interacting genes: CDK4 EIF4E FHL3 LSM3 MTOR RPTOR
Entrez ID		27258	1979
HPRD ID		06283	03747
Ensembl ID		ENSG00000170860	ENSG00000148730
Uniprot IDs		P62310	A0A024QZM3 Q13542
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	2MX4 3AM7
Enriched GO Terms of Interacting Partners?
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