LSM3 and DLX4

Data Source:
BioGRID (two hybrid)

		LSM3	DLX4
Description		LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated	distal-less homeobox 4
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm U6 SnRNP Cytosol U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome Precatalytic Spliceosome Catalytic Step 2 Spliceosome Lsm2-8 Complex Lsm1-7-Pat1 Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Binding Protein Binding U6 SnRNA 3'-end Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing P-body Assembly Exonucleolytic Catabolism Of Deadenylated MRNA	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Multicellular Organism Development Embryo Development Cell Differentiation
Pathways		mRNA decay by 5' to 3' exoribonuclease mRNA decay by 5' to 3' exoribonuclease mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Height ( 31562340) Offspring birth weight ( 31043758) PR interval ( 32439900) Red blood cell count ( 32888494)	Blond vs. brown/black hair color ( 30531825) Blood urea nitrogen levels ( 29403010) Cognitive decline rate in late mild cognitive impairment ( 26252872) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Serum alkaline phosphatase levels ( 29403010)
Interacting Genes		48 interacting genes: CCND3 CDKN2D CEP95 CLNS1A CNOT7 DDIT4L DLX4 EEF1A1 EIF4EBP2 EXOSC1 EXOSC5 GDF9 GSTA1 HSPB1 INCA1 KEAP1 KLF3 LSM1 LSM10 LSM12 LSM2 LSM5 LSM6 LSM7 LSM8 NACC1 PIAS1 QKI SF3B2 SH3GLB2 SMN1 SNRPD1 SNRPD3 SNRPE SNRPF SNRPG TCL1A TEPSIN TFIP11 THOC5 TRAPPC2 TRAPPC2B UTP14A WDR77 WDR83 XPC XRN2 YBX1	3 interacting genes: DNMT3L LSM3 MAGED1
Entrez ID		27258	1748
HPRD ID		06283	03553
Ensembl ID		ENSG00000170860	ENSG00000108813
Uniprot IDs		P62310	Q92988
PDB IDs		3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9
Enriched GO Terms of Interacting Partners?
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