ABHD5 and GRIA4

Data Source:
BioGRID (two hybrid)

		ABHD5	GRIA4
Description		abhydrolase domain containing 5, lysophosphatidic acid acyltransferase	glutamate ionotropic receptor AMPA type subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Lipid Droplet Cytosol Intracellular Membrane-bounded Organelle	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Extracellular Vesicle
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Triglyceride Lipase Activity Protein Binding Lysophosphatidic Acid Acyltransferase Activity Carboxylic Ester Hydrolase Activity	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity
	Biological Process	Fatty Acid Metabolic Process Phosphatidic Acid Biosynthetic Process Negative Regulation Of Sequestering Of Triglyceride Positive Regulation Of Triglyceride Catabolic Process Cell Differentiation Positive Regulation Of Lipoprotein Lipase Activity Lipid Homeostasis	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of NMDA Receptor Activity
Pathways		Triglyceride catabolism	Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules
Drugs			Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)
Diseases		Dorfman-Chanarin syndrome; Chanarin-Dorfman syndrome
GWAS		General risk tolerance (MTAG) ( 30643258) Inflammatory skin disease ( 25574825)	Age at first sexual intercourse ( 27089180) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)
Interacting Genes		21 interacting genes: CERCAM COQ8A DGAT2L6 GAD2 GET1 GRIA4 MIEF1 PCNX2 PLIN1 PLIN2 PLIN3 PNPLA2 RBFA RNF24 RUSC1 SH3GLB1 SLC44A3 TMEM14B TMEM31 TPD52L2 ZCCHC12	13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP
Entrez ID		51099	2893
HPRD ID		11986	00694
Ensembl ID		ENSG00000011198	ENSG00000152578
Uniprot IDs		A0A0S2Z5D6 Q8WTS1	P48058 Q1WWK6
PDB IDs
Enriched GO Terms of Interacting Partners?
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