GRIA4 and CACNG2

Data Source:
HPRD (in vivo)

		GRIA4	CACNG2
Description		glutamate ionotropic receptor AMPA type subunit 4	calcium voltage-gated channel auxiliary subunit gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Extracellular Vesicle	Cytosol Plasma Membrane Voltage-gated Calcium Channel Complex Cell Surface Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Somatodendritic Compartment Cerebellar Mossy Fiber Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Postsynaptic Density Membrane Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity	Voltage-gated Calcium Channel Activity Protein Binding Channel Regulator Activity Ionotropic Glutamate Receptor Binding
	Biological Process	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of NMDA Receptor Activity	Protein Targeting To Membrane Neuromuscular Junction Development Transmission Of Nerve Impulse Response To Calcium Ion Membrane Depolarization Positive Regulation Of Synaptic Transmission, Glutamatergic Membrane Hyperpolarization Eye Blink Reflex Cardiac Conduction Calcium Ion Transmembrane Transport Neurotransmitter Receptor Transport, Postsynaptic Endosome To Lysosome Postsynaptic Neurotransmitter Receptor Diffusion Trapping Neurotransmitter Receptor Internalization Positive Regulation Of Protein Localization To Basolateral Plasma Membrane Regulation Of AMPA Receptor Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Presynaptic depolarization and calcium channel opening Trafficking of AMPA receptors LGI-ADAM interactions
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)	Ergocalciferol Enflurane Spironolactone Ethanol Butamben Bioallethrin
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Airway responsiveness in chronic obstructive pulmonary disease ( 25514360)
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	11 interacting genes: APP DLG1 DLG2 DLG3 DLG4 GRIA1 GRIA4 PATJ PRKACA SRPK2 WIPF1
Entrez ID		2893	10369
HPRD ID		00694	04220
Ensembl ID		ENSG00000152578	ENSG00000166862
Uniprot IDs		P48058 Q1WWK6	Q9Y698
PDB IDs			6DLZ 6DM0 6DM1 6O9G
Enriched GO Terms of Interacting Partners?
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