GRIA4 and EPB41L1

Data Source:
BioGRID (pull down)
HPRD (in vivo, in vitro)

		GRIA4	EPB41L1
Description		glutamate ionotropic receptor AMPA type subunit 4	erythrocyte membrane protein band 4.1 like 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Endocytic Vesicle Membrane AMPA Glutamate Receptor Complex Neuronal Cell Body Dendritic Spine Postsynaptic Membrane Extracellular Vesicle	Cytosol Cytoskeleton Plasma Membrane
	Molecular Function	Amyloid-beta Binding Ionotropic Glutamate Receptor Activity AMPA Glutamate Receptor Activity Ligand-gated Ion Channel Activity Signaling Receptor Activity	Actin Binding Structural Molecule Activity Protein Binding
	Biological Process	Glutamate Receptor Signaling Pathway Ion Transmembrane Transport Ionotropic Glutamate Receptor Signaling Pathway Regulation Of NMDA Receptor Activity	Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization
Pathways		Activation of AMPA receptors Trafficking of AMPA receptors Trafficking of GluR2-containing AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Synaptic adhesion-like molecules	Trafficking of AMPA receptors Neurexins and neuroligins
Drugs		Glutamic acid Butabarbital Ethanol Talampanel CX-717 Fluciclovine (18F)
Diseases
GWAS		Age at first sexual intercourse ( 27089180) Myopia ( 27182965) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Post bronchodilator FEV1 ( 26634245) Refractive error ( 23396134 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Height ( 23563607) Hip circumference ( 25673412) Keratinocyte cancer (MTAG) ( 31174203) Refractive error ( 32231278)
Interacting Genes		13 interacting genes: ABHD5 ACTN1 CACNG2 CAMK2G EPB41L1 GRIA1 GRIP1 IQGAP1 PICK1 PRKACA PRKCA PRKCG SDCBP	19 interacting genes: AGAP2 APP ARHGAP1 CHRM5 DRD2 DRD3 GRIA1 GRIA4 HSPB1 ITPR1 NR3C1 NUMA1 POT1 SRPK2 STARD13 TERF1 YWHAB YWHAQ YWHAZ
Entrez ID		2893	2036
HPRD ID		00694	04193
Ensembl ID		ENSG00000152578	ENSG00000088367
Uniprot IDs		P48058 Q1WWK6	A0A0C4DH22 B7Z653 Q9H4G0
PDB IDs
Enriched GO Terms of Interacting Partners?
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