PACSIN3 and ASAP1

Data Source:
HPRD (two hybrid)

		PACSIN3	ASAP1
Description		protein kinase C and casein kinase substrate in neurons 3	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Cytosol Cytoskeleton Plasma Membrane Extracellular Exosome	Podosome Cytosol Cell Projection Membrane Dendritic Spine
	Molecular Function	Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Lipid Binding Calcium Channel Inhibitor Activity Identical Protein Binding	Phosphatidylserine Binding GTPase Activator Activity Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Cadherin Binding Metal Ion Binding
	Biological Process	Endocytosis Cytoskeleton Organization Regulation Of Endocytosis Negative Regulation Of Endocytosis Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Plasma Membrane Tubulation	Positive Regulation Of GTPase Activity Cilium Assembly Negative Regulation Of Dendritic Spine Development Positive Regulation Of Podosome Assembly Positive Regulation Of Membrane Tubulation
Pathways		Clathrin-mediated endocytosis	VxPx cargo-targeting to cilium VxPx cargo-targeting to cilium
Drugs
Diseases
GWAS		Alzheimer's disease or fasting glucose levels (pleiotropy) ( 30805717) Autism spectrum disorder or schizophrenia ( 28540026) Waist-to-hip ratio adjusted for body mass index ( 26785701)	Diisocyanate-induced asthma ( 25918132) Mean corpuscular volume ( 32888494) Mean platelet volume ( 32888494 27863252) Multiple sclerosis ( 19525955) Nevus count or cutaneous melanoma ( 32341527) Platelet count ( 27863252) Platelet distribution width ( 32888494) Post bronchodilator FEV1 in COPD ( 26634245) Progressive supranuclear palsy ( 30089514) Refractive error ( 32231278) Tuberculosis ( 25774636) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		23 interacting genes: ADAM12 ADAM15 ASAP1 ASAP2 ATXN7L2 CLNK DNM1 ITSN1 KRTAP12-2 LGALS13 PACSIN1 PACSIN2 PAK2 RAF1 SMARCD1 SOS1 SOS2 SPRY2 SYNJ1 TERF2IP TNPO2 TRPV4 WASL	15 interacting genes: ARF1 ARF6 CBL CRK DNAJB6 GRB2 HCK PACSIN3 PTK2 PTK2B PXN RAB11FIP3 REPS2 SH3KBP1 SRC
Entrez ID		29763	50807
HPRD ID		05937	05809
Ensembl ID		ENSG00000165912	ENSG00000153317
Uniprot IDs		Q9UKS6	A0A0A0MRE5 Q9ULH1
PDB IDs			2D1X 2DA0 2ED1 2RQT 2RQU
Enriched GO Terms of Interacting Partners?
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