PARN and PALS2

Data Source:
BioGRID (two hybrid)

		PARN	PALS2
Description		poly(A)-specific ribonuclease	protein associated with LIN7 2, MAGUK family member
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck	Plasma Membrane Membrane Extracellular Exosome
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA RNA 3'-end Processing Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Positive Regulation Of Telomerase Activity Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Telomerase RNA Stabilization NcRNA Deadenylation Regulation Of Telomerase RNA Localization To Cajal Body	Protein-containing Complex Assembly
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		6 interacting genes: KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2	30 interacting genes: AATF ABCA1 ARHGAP18 DIS3 DNM2 DYNLRB1 EIF3G EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FTL KHDRBS1 KNSTRN LIN7A LIN7B LIN7C MT2P1 MTREX NDN NFKB1 PARN RPS20 SMARCA4 SNX9 THOP1
Entrez ID		5073	51678
HPRD ID		07250	09509
Ensembl ID		ENSG00000140694	ENSG00000105926
Uniprot IDs		A0A494C0Q2 A0A494C1K5 B3KN69 O95453	A0A024RA25 B8ZZG1 Q9NZW5
PDB IDs		2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?
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