PARN and KHSRP

Data Source:
HPRD (in vivo, in vitro)

		PARN	KHSRP
Description		poly(A)-specific ribonuclease	KH-type splicing regulatory protein
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA RNA 3'-end Processing Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Positive Regulation Of Telomerase Activity Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Telomerase RNA Stabilization NcRNA Deadenylation Regulation Of Telomerase RNA Localization To Cajal Body	RNA Splicing, Via Transesterification Reactions Regulation Of Transcription, DNA-templated MRNA Processing RNA Splicing Regulation Of Gene Expression MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA	ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs			Resveratrol Artenimol
Diseases
GWAS		Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		6 interacting genes: KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2	14 interacting genes: A1CF APBB1 BACE1 EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 KLHL12 PARN PTBP2 STK3 UBE2I
Entrez ID		5073	8570
HPRD ID		07250	10350
Ensembl ID		ENSG00000140694	ENSG00000088247
Uniprot IDs		A0A494C0Q2 A0A494C1K5 B3KN69 O95453	Q92945
PDB IDs		2A1R 2A1S 3CTR	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
Enriched GO Terms of Interacting Partners?
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