PARN and SPATC1L

Data Source:
HPRD (two hybrid)

		PARN	SPATC1L
Description		poly(A)-specific ribonuclease	spermatogenesis and centriole associated 1 like
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Nuclear Speck	Cellular_component Centrosome Sperm Connecting Piece
	Molecular Function	3'-5'-exoribonuclease Activity RNA Binding MRNA 3'-UTR Binding Nuclease Activity Poly(A)-specific Ribonuclease Activity Protein Binding Protein Kinase Binding Cation Binding Metal Ion Binding Telomerase RNA Binding	Molecular_function Protein Binding Protein Kinase A Regulatory Subunit Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening Box H/ACA RNA 3'-end Processing Female Gamete Generation RNA Modification MiRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of MRNA Stability Positive Regulation Of Telomerase Activity Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Telomerase RNA Stabilization NcRNA Deadenylation Regulation Of Telomerase RNA Localization To Cajal Body	Spermatogenesis Biological_process Actin Polymerization Or Depolymerization Positive Regulation Of Protein Kinase A Signaling Positive Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress Deadenylation of mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Height ( 25429064) Male-pattern baldness ( 27182965) Menarche (age at onset) ( 27182965) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311)
Interacting Genes		6 interacting genes: KHSRP MAPKAPK2 MPHOSPH6 PALS2 SPATC1L SUMO2	46 interacting genes: ACOT7 ARL4A ARMC7 ATPAF2 CABP2 DISC1 EXOSC8 FOXN1 FSD2 GOLGA6A GTF3C6 HOOK2 IKZF1 KIFC3 KRT40 KRTAP5-9 LZTS2 MISP MTUS2 MYO15B NCK2 NUTF2 NXF1 PARN PHC2 PHF11 PIAS2 PICK1 PNMA1 POLR1C PPP1CB PPP1CC QARS1 RAD51D RBMY1F RBMY1J REL SIAH1 SYCE1 TCF4 TEKT4 TRIM27 TRMO TSR2 UBL5 ZBTB8B
Entrez ID		5073	84221
HPRD ID		07250	10753
Ensembl ID		ENSG00000140694	ENSG00000160284
Uniprot IDs		A0A494C0Q2 A0A494C1K5 B3KN69 O95453	Q9H0A9
PDB IDs		2A1R 2A1S 3CTR
Enriched GO Terms of Interacting Partners?
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