PRDX1 and AXIN2

Data Source:
BioGRID (two hybrid)

		PRDX1	AXIN2
Description		peroxiredoxin 1	axin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Nucleus Cytoplasm Centrosome Cytosol Beta-catenin Destruction Complex
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cadherin Binding	Protein Binding Beta-catenin Binding Enzyme Binding Ubiquitin Protein Ligase Binding I-SMAD Binding
	Biological Process	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Cellular Response To Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis	Somitogenesis Positive Regulation Of Protein Phosphorylation Intramembranous Ossification Secondary Heart Field Specification Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Cell Death Wnt Signaling Pathway Bone Mineralization Regulation Of Mismatch Repair Cellular Protein Localization Odontogenesis Maintenance Of DNA Repeat Elements Negative Regulation Of Osteoblast Differentiation MRNA Stabilization Regulation Of Chondrocyte Development Regulation Of Centromeric Sister Chromatid Cohesion Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	TCF dependent signaling in response to WNT Binding of TCF/LEF:CTNNB1 to target gene promoters Degradation of AXIN Ub-specific processing proteases
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases			Tooth agenesis; Hypodontia Oligodontia-colorectal cancer syndrome
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)	Blond vs. brown/black hair color ( 30531825) Heel bone mineral density ( 30598549 28869591) Height ( 31562340) Refractive error ( 32231278)
Interacting Genes		29 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	52 interacting genes: AMOT ANKRD6 AP1M1 APC APC2 BARD1 BTRC BYSL C2orf68 CAPN7 CCDC112 CHIC2 CSNK1E CTAG2 CTNNB1 CWF19L2 ELOA FAM161A FBP1 FBP2 GSK3B HEMGN HOXB5 KCNK12 KIFC3 KRTAP10-10 KRTAP10-8 KRTAP4-5 KRTAP9-2 LNX1 MCRS1 PPP2R5A PRDX1 PSMB2 RANGAP1 SCNM1 SMAD1 SMAD3 SMAD7 STX11 TCEA2 TCEANC TGFB1 TOP3B TSGA10 TXLNA TXLNB ZNF124 ZNF189 ZNF417 ZNF587 ZNF648
Entrez ID		5052	8313
HPRD ID		01458	04935
Ensembl ID		ENSG00000117450	ENSG00000168646
Uniprot IDs		A0A384NPQ2 Q06830	E7ES00 Q9Y2T1
PDB IDs		2RII 3HY2 4XCS
Enriched GO Terms of Interacting Partners?
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