PRDX1 and MYD88

Data Source:
BioGRID (two hybrid)

		PRDX1	MYD88
Description		peroxiredoxin 1	MYD88 innate immune signal transduction adaptor
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Melanosome Extracellular Exosome	Nucleus Cytoplasm Cytosol Plasma Membrane Endosome Membrane Postsynaptic Density Protein-containing Complex
	Molecular Function	RNA Binding Peroxidase Activity Protein Binding Thioredoxin Peroxidase Activity Cadherin Binding	Toll Binding Death Receptor Binding Interleukin-1 Receptor Binding Protein Binding Toll-like Receptor Binding Identical Protein Binding Protein Self-association TIR Domain Binding
	Biological Process	Skeletal System Development Retina Homeostasis Response To Oxidative Stress Cell Population Proliferation Removal Of Superoxide Radicals Natural Killer Cell Activation Cellular Response To Stress Cellular Response To Oxidative Stress Hydrogen Peroxide Catabolic Process Leukocyte Activation Cell Redox Homeostasis	Toll-like Receptor Signaling Pathway Response To Molecule Of Fungal Origin MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Apoptotic Process Inflammatory Response Signal Transduction Cell Surface Receptor Signaling Pathway JNK Cascade Toll Signaling Pathway Response To Virus Induced Systemic Resistance Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Type I Interferon Production Response To Peptidoglycan Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-23 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 9 Signaling Pathway Defense Response To Bacterium Defense Response To Protozoan Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Lymphocyte Proliferation Regulation Of Inflammatory Response Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Type I Interferon Signaling Pathway Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 3'-UTR-mediated MRNA Stabilization Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Establishment Of Endothelial Intestinal Barrier Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Regulation Of Neutrophil Migration Regulation Of Chemokine (C-X-C Motif) Ligand 1 Production Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		Detoxification of Reactive Oxygen Species TP53 Regulates Metabolic Genes Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models	ER-Phagosome pathway PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane RIP-mediated NFkB activation via ZBP1 p75NTR recruits signalling complexes p75NTR recruits signalling complexes DEx/H-box helicases activate type I IFN and inflammatory cytokines production MyD88 deficiency (TLR2/4) MyD88 deficiency (TLR5) IRAK4 deficiency (TLR5) IRAK4 deficiency (TLR2/4) PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Interleukin-1 signaling TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome MyD88 cascade initiated on plasma membrane
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Blood protein levels ( 28240269) Body mass index ( 26426971) Hemoglobin ( 32888494)	Gut microbiota (bacterial taxa) ( 27723756) Mean corpuscular hemoglobin concentration ( 29403010)
Interacting Genes		29 interacting genes: ABL1 ADH5 ADRB2 AXIN2 BTRC CALM1 CCR4 CLEC4G EGFR GAPDH IRF3 LUC7L MTRNR2L1 MYC MYD88 PPP2R1A PPP2R1B PRDX4 PTEN PTGER4 SESN1 SESN2 SH2D1B SMARCD1 SNCA TERF1 UBE3A VHL YWHAQ	43 interacting genes: BTK CD93 CISH FADD FLII IKBKG IL1R1 IL1RAP IL1RL1 IRAK1 IRAK2 IRAK3 IRAK4 IRF4 IRF5 IRF7 MAL MBIP MDM2 NTAQ1 PELI2 PFKL POLR1C PRDX1 RAC1 RNF4 SARM1 SIAH2 SMAD3 SPOP SPOPL STAP2 TIRAP TLR10 TLR2 TLR3 TLR4 TLR5 TLR7 TLR8 TXN USP7 ZNF35
Entrez ID		5052	4615
HPRD ID		01458	03703
Ensembl ID		ENSG00000117450	ENSG00000172936
Uniprot IDs		A0A384NPQ2 Q06830	A0A0A0MSI9 A0A3B3ITY3 A0A3F2YP85 Q99836
PDB IDs		2RII 3HY2 4XCS	2JS7 2Z5V 3MOP 4DOM 4EO7 6I3N
Enriched GO Terms of Interacting Partners?
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