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MCM7 and RPA1
Data Source:
BioGRID
(two hybrid)
HPRD
(two hybrid)
MCM7
RPA1
Description
minichromosome maintenance complex component 7
replication protein A1
Image
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Chromatin
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Membrane
MCM Complex
CMG Complex
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
DNA Replication Factor A Complex
PML Body
Site Of DNA Damage
Molecular Function
DNA Binding
DNA Helicase Activity
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Single-stranded 3'-5' DNA Helicase Activity
Damaged DNA Binding
Single-stranded DNA Binding
Protein Binding
Single-stranded Telomeric DNA Binding
Metal Ion Binding
G-rich Strand Telomeric DNA Binding
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
DNA Strand Elongation Involved In DNA Replication
Cellular Response To DNA Damage Stimulus
Cell Population Proliferation
Regulation Of Phosphorylation
Response To Drug
Cellular Response To Epidermal Growth Factor Stimulus
Cellular Response To Xenobiotic Stimulus
G1/S Transition Of Mitotic Cell Cycle
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
DNA Replication
DNA-dependent DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Base-excision Repair
Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Mismatch Repair
DNA Recombination
Cellular Response To DNA Damage Stimulus
Telomere Maintenance Via Telomerase
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
Nucleotide-excision Repair, DNA Incision
Protein Localization To Chromosome
Interstrand Cross-link Repair
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Meiotic Cell Cycle
Error-free Translesion Synthesis
Regulation Of Cellular Response To Heat
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Removal of the Flap Intermediate from the C-strand
Activation of ATR in response to replication stress
SUMOylation of DNA damage response and repair proteins
Regulation of HSF1-mediated heat shock response
HSF1 activation
Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Formation of Incision Complex in GG-NER
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Fanconi Anemia Pathway
Regulation of TP53 Activity through Phosphorylation
Activation of the pre-replicative complex
Removal of the Flap Intermediate
G2/M DNA damage checkpoint
Meiotic recombination
Drugs
Diseases
GWAS
Brain morphology (MOSTest) (
32665545
)
Refractive error (
32231278
)
Subcortical volume (MOSTest) (
32665545
)
Airway imaging phenotypes (
26030696
)
Bipolar disorder (
31043756
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
27863252
)
Mean reticulocyte volume (
32888494
)
Mean spheric corpuscular volume (
32888494
)
Metabolite levels (
23823483
)
Interacting Genes
77 interacting genes:
ABI2
AK8
APP
ASB8
C8orf34
CCDC102B
CCND1
CCNH
CDC42
CDC45
CDC6
CDC7
CDK7
CDKN1B
CEP68
CHEK1
COG6
CRLS1
DBF4
DNAAF6
DUX4
ELOC
ESCO2
FHL2
GOLGA2
H3-4
HIF1A
IKBKG
IKZF3
INTS6
KIFC3
LINC01554
LNX2
MAGEA6
MBIP
MCM10
MCM2
MCM3
MCM4
MCM5
MCM6
MCM8
MCMBP
MEOX2
MIPOL1
MNAT1
NAB2
NFKBIA
ORC1
ORC2
ORC3
ORC4
ORC5
ORC6
PLK1
PNMA1
RAD17
RB1
RBL1
RBL2
RBM8A
RBPMS
RINT1
RPA1
SMC1A
SNTA1
SP2
SSX2IP
TFIP11
TREX1
TRIM27
TRIM54
TRIM55
TRIM63
UBE3A
UBQLN1
USHBP1
68 interacting genes:
AICDA
AKTIP
ANXA1
ANXA7
ASCC2
ATM
BID
BLM
BRCA2
BRIP1
CCNA1
CCNA2
CCNB1
CDC5L
CPE
CSNK2B
DMC1
EHMT2
ERCC1
ERCC4
EXO5
GNB5
HAX1
HELB
HGH1
HNRNPUL1
HSPA6
HUS1
MCM2
MCM4
MCM6
MCM7
MMS22L
MSH4
MTUS2
MUTYH
ORC2
ORC6
PAXIP1
PCNA
POLL
PRIMPOL
PRKDC
RAD1
RAD23B
RAD51
RAD52
RAD9A
RBM23
RCC1
RECQL
RFWD3
RPA2
RPA3
RPA4
RPS6KA5
SELENBP1
SEM1
SMAD3
TCEA2
TK1
TP53
TREX1
VIM
WRN
XPA
XPC
ZBTB14
Entrez ID
4176
6117
HPRD ID
01154
01565
Ensembl ID
ENSG00000166508
ENSG00000132383
Uniprot IDs
A0A0S2Z4A5
C6EMX8
P33993
P27694
PDB IDs
6XTX
6XTY
1EWI
1FGU
1JMC
1L1O
2B29
2B3G
4IJH
4IJL
4IPC
4IPD
4IPG
4IPH
4LUO
4LUV
4LUZ
4LW1
4LWC
4NB3
4O0A
4R4C
4R4I
4R4O
4R4Q
4R4T
5E7N
5EAY
5N85
5N8A
Enriched GO Terms of Interacting Partners
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