MCM7 and RBL2

Data Source:
HPRD (in vitro)

		MCM7	RBL2
Description		minichromosome maintenance complex component 7	RB transcriptional corepressor like 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus Cytosol Membrane MCM Complex CMG Complex	Chromatin Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	DNA Binding DNA Helicase Activity DNA Replication Origin Binding Single-stranded DNA Binding Protein Binding ATP Binding Single-stranded 3'-5' DNA Helicase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication DNA Replication Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication DNA Unwinding Involved In DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication Cellular Response To DNA Damage Stimulus Cell Population Proliferation Regulation Of Phosphorylation Response To Drug Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Chromatin Organization Regulation Of Transcription By RNA Polymerase II DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Division Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Body fat mass ( 28552196) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Metabolite levels ( 23823483)
Interacting Genes		77 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEP68 CHEK1 COG6 CRLS1 DBF4 DNAAF6 DUX4 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MCMBP MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM55 TRIM63 UBE3A UBQLN1 USHBP1	44 interacting genes: BRCA1 BRF1 BRF2 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		4176	5934
HPRD ID		01154	01576
Ensembl ID		ENSG00000166508	ENSG00000103479
Uniprot IDs		A0A0S2Z4A5 C6EMX8 P33993	Q08999
PDB IDs		6XTX 6XTY	4XI9 5C1D
Enriched GO Terms of Interacting Partners?
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