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MCM6 and CCNA1
Data Source:
HPRD
(in vitro)
MCM6
CCNA1
Description
minichromosome maintenance complex component 6
cyclin A1
Image
No pdb structure
GO Annotations
Cellular Component
Chromosome, Telomeric Region
Nucleus
Nucleoplasm
MCM Complex
CMG Complex
Cyclin-dependent Protein Kinase Holoenzyme Complex
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Microtubule Cytoskeleton
Cyclin A1-CDK2 Complex
Cyclin A2-CDK2 Complex
Molecular Function
DNA Helicase Activity
DNA Replication Origin Binding
Single-stranded DNA Binding
Protein Binding
ATP Binding
Identical Protein Binding
Single-stranded 3'-5' DNA Helicase Activity
Protein Binding
Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity
Biological Process
G1/S Transition Of Mitotic Cell Cycle
Double-strand Break Repair Via Break-induced Replication
DNA Replication
Pre-replicative Complex Assembly Involved In Nuclear Cell Cycle DNA Replication
DNA Unwinding Involved In DNA Replication
DNA Replication Initiation
Mitotic DNA Replication
Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity
Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle
Male Meiosis I
Spermatogenesis
Protein Deubiquitination
Mitotic Cell Cycle Phase Transition
Cell Division
Pathways
Activation of ATR in response to replication stress
Unwinding of DNA
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex
Switching of origins to a post-replicative state
G0 and Early G1
Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes
Telomere Extension By Telomerase
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Regulation of APC/C activators between G1/S and early anaphase
SCF(Skp2)-mediated degradation of p27/p21
Senescence-Associated Secretory Phenotype (SASP)
DNA Damage/Telomere Stress Induced Senescence
Ub-specific processing proteases
Processing of DNA double-strand break ends
TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest
Regulation of TP53 Activity through Phosphorylation
Regulation of TP53 Degradation
G2 Phase
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G1/S-Specific Transcription
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A/B1/B2 associated events during G2/M transition
p53-Dependent G1 DNA Damage Response
Cyclin A:Cdk2-associated events at S phase entry
Drugs
Diseases
GWAS
Body mass index (
25673413
)
Gut microbiota (bacterial taxa, rank normal transformation method) (
32572223
)
Hip circumference (
25673412
)
Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes (
28736931
)
Cocaine dependence (
31212010
)
Nickel levels (
26025379
)
Interacting Genes
38 interacting genes:
C2CD6
CCNA1
CDC42
CDC45
CDC7
CDKN2A
CDT1
CHEK1
CRLS1
DBF4
ESCO2
FAM161A
GMNN
HSPB1
IL36RN
ING5
MCM10
MCM2
MCM3
MCM4
MCM7
MCM8
MCMBP
MLLT3
MTDH
NUDT2
ORC1
ORC2
ORC4
ORC6
PSMA1
RPA1
SCNM1
SMC1A
SNRPB2
TRIM28
UBE3A
ZBTB9
35 interacting genes:
ARID2
BRCA1
BRCA2
CABLES1
CDC20
CDC25A
CDK1
CDK2
CDKN1A
CDKN1B
CKS1B
CKS2
CUX1
E2F1
GPS2
H1-1
H1-5
H2BC1
INCA1
KLHDC9
MCM4
MCM6
MYBL2
NPAT
PGR
PROCA1
RACK1
RB1
RBL1
RBL2
RBM4
RPA1
SP1
SRC
XRCC6
Entrez ID
4175
8900
HPRD ID
03485
04946
Ensembl ID
ENSG00000076003
ENSG00000133101
Uniprot IDs
Q14566
A0A140VJG0
P78396
PDB IDs
2KLQ
2LE8
6XTX
6XTY
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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