MBP and PRKCI

Data Source:
BioGRID (enzymatic study)
HPRD (in vitro)

		MBP	PRKCI
Description		myelin basic protein	protein kinase C iota
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Golgi Membrane Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Intercellular Bridge Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Peptidyl-serine Phosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Glucose Import Secretion Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Bicellular Tight Junction Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions
Drugs			Tamoxifen Bisindolylmaleimide I Fostamatinib
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Microalbuminuria ( 31511532) Prostate cancer ( 25939597) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)
Interacting Genes		81 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	52 interacting genes: ADAP1 ANXA1 APP BAD CASK CASP8 CCNT1 CDC42 CDK7 CHUK CTBP1 FABP4 FCGR3A FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MAPT MARK4 MBP MEOX2 NACC1 NFKBIA PARD3 PARD6A PARD6B PARD6G PCM1 PDPK1 PNMA1 RAB2A RAB4A RAC1 RBM14 RHOQ RPA2 SMG1 SMURF1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ
Entrez ID		4155	5584
HPRD ID		01158	02105
Ensembl ID		ENSG00000197971	ENSG00000163558
Uniprot IDs		A0A024R384 P02686	P41743
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL	1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH 6ILZ
Enriched GO Terms of Interacting Partners?
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