MBP and MAPK13

Data Source:
HPRD (in vitro)

		MBP	MAPK13
Description		myelin basic protein	mitogen-activated protein kinase 13
Image
GO Annotations	Cellular Component	Nucleus Plasma Membrane Cell Surface Protein-containing Complex Internode Region Of Axon Neuronal Cell Body Myelin Sheath Compact Myelin Synapse Cell Periphery	Nucleus Cytoplasm Cytosol
	Molecular Function	Protease Binding Protein Binding Calmodulin Binding Structural Constituent Of Myelin Sheath	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Immune Response Chemical Synaptic Transmission Central Nervous System Development Sensory Perception Of Sound Axon Ensheathment Response To Toxic Substance Substantia Nigra Development Positive Regulation Of Interleukin-6 Production Negative Regulation Of Heterotypic Cell-cell Adhesion Maintenance Of Blood-brain Barrier Myelination Membrane Organization Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Response To Osmotic Stress Cell Cycle Peptidyl-serine Phosphorylation Positive Regulation Of Interleukin-6 Production Cellular Response To UV Intracellular Signal Transduction Positive Regulation Of Inflammatory Response Stress-activated MAPK Cascade Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Sorbitol Cellular Response To Anisomycin Cellular Response To Sodium Arsenite
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination	NOD1/2 Signaling Pathway p38MAPK events DSCAM interactions VEGFA-VEGFR2 Pathway
Drugs			Minocycline KC706 Fostamatinib
Diseases
GWAS		Age-related macular degeneration (geographic atrophy) ( 22705344) Blood osmolality (transformed sodium) ( 28360221) Depression in smokers ( 30219690) Erythrocyte cadmium concentration in never smokers ( 27005419) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Verbal declarative memory ( 25648963)	Birth weight ( 31043758) Blood protein levels ( 30072576 29875488) Offspring birth weight ( 31043758)
Interacting Genes		81 interacting genes: ABL1 ADRB2 APTX ATN1 ATXN1 AURKA BMP2K CCR1 CDK1 CDK12 CDK5 CDK7 CDK8 CDK9 CLK1 CTDSP1 CTDSPL DYRK1B HIPK2 HLA-DRA IKBKE ILK IRAK1 IRAK4 LIMK1 LIMK2 LRRK2 MAG MAP2K1 MAP3K1 MAP3K3 MAP3K5 MAPK1 MAPK11 MAPK12 MAPK13 MAPK14 MAPK15 MAPK3 MAPK8 MAPKAPK5 MELK MICU2 MKNK1 MMP7 NEK9 PAK1 PDGFRL PKN1 PLEKHF2 PLP1 PPP2R5C PRKACA PRKCA PRKCB PRKCD PRKCI PRKCZ PRKDC PRMT1 PRMT5 PTAFR PTPRA RAF1 RAN RPS6KA5 RTN4 SQSTM1 SRPK1 STK16 STK26 STK3 STK39 STK4 TBK1 TLK1 TLK2 TRAF6 TRPM7 TSSK6 ULK1	16 interacting genes: AKIP1 ANKLE2 APP ATF2 EEF2K FGF12 GPX4 HTRA2 MAP2K6 MAP3K4 MAPKAPK3 MAPKAPK5 MAPT MBP SMAD4 SQSTM1
Entrez ID		4155	5603
HPRD ID		01158	09113
Ensembl ID		ENSG00000197971	ENSG00000156711
Uniprot IDs		A0A024R384 P02686	A0A024RD04 O15264
PDB IDs		1BX2 1FV1 1HQR 1K2D 1QCL 1YMM 1ZGL	3COI 4EYJ 4EYM 4MYG 4YNO 5EKN 5EKO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?