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MBP and STK3
Data Source:
BioGRID
(enzymatic study)
MBP
STK3
Description
myelin basic protein
serine/threonine kinase 3
Image
GO Annotations
Cellular Component
Nucleus
Plasma Membrane
Cell Surface
Protein-containing Complex
Internode Region Of Axon
Neuronal Cell Body
Myelin Sheath
Compact Myelin
Synapse
Cell Periphery
Nucleus
Cytoplasm
Cytosol
Protein-containing Complex
Molecular Function
Protease Binding
Protein Binding
Calmodulin Binding
Structural Constituent Of Myelin Sheath
Magnesium Ion Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
Identical Protein Binding
Protein Serine/threonine Kinase Activator Activity
Protein Serine Kinase Activity
Protein Threonine Kinase Activity
Biological Process
MAPK Cascade
Immune Response
Chemical Synaptic Transmission
Central Nervous System Development
Sensory Perception Of Sound
Axon Ensheathment
Response To Toxic Substance
Substantia Nigra Development
Positive Regulation Of Interleukin-6 Production
Negative Regulation Of Heterotypic Cell-cell Adhesion
Maintenance Of Blood-brain Barrier
Myelination
Membrane Organization
Positive Regulation Of Metalloendopeptidase Activity
Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Neural Tube Formation
Endocardium Development
Protein Phosphorylation
Apoptotic Process
Central Nervous System Development
Negative Regulation Of Cell Population Proliferation
Stress-activated Protein Kinase Signaling Cascade
Positive Regulation Of Protein Binding
Activation Of Protein Kinase Activity
Hippo Signaling
Intracellular Signal Transduction
Positive Regulation Of Apoptotic Process
Positive Regulation Of Fat Cell Differentiation
Positive Regulation Of JNK Cascade
Negative Regulation Of Organ Growth
Protein Stabilization
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of Protein Kinase B Signaling
Primitive Hemopoiesis
Cell Differentiation Involved In Embryonic Placenta Development
Regulation Of Cell Differentiation Involved In Embryonic Placenta Development
Positive Regulation Of Protein Serine/threonine Kinase Activity
Negative Regulation Of Canonical Wnt Signaling Pathway
Hepatocyte Apoptotic Process
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors
Pathways
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Signaling by Hippo
Drugs
Fostamatinib
Diseases
GWAS
Age-related macular degeneration (geographic atrophy) (
22705344
)
Blood osmolality (transformed sodium) (
28360221
)
Depression in smokers (
30219690
)
Erythrocyte cadmium concentration in never smokers (
27005419
)
Paclitaxel disposition in epithelial ovarian cancer (
29367611
)
Verbal declarative memory (
25648963
)
Depressive symptom improvement (
30468137
)
Heel bone mineral density (
30598549
)
Rosacea symptom severity (
29771307
)
Suicide behavior (
26079190
)
Interacting Genes
81 interacting genes:
ABL1
ADRB2
APTX
ATN1
ATXN1
AURKA
BMP2K
CCR1
CDK1
CDK12
CDK5
CDK7
CDK8
CDK9
CLK1
CTDSP1
CTDSPL
DYRK1B
HIPK2
HLA-DRA
IKBKE
ILK
IRAK1
IRAK4
LIMK1
LIMK2
LRRK2
MAG
MAP2K1
MAP3K1
MAP3K3
MAP3K5
MAPK1
MAPK11
MAPK12
MAPK13
MAPK14
MAPK15
MAPK3
MAPK8
MAPKAPK5
MELK
MICU2
MKNK1
MMP7
NEK9
PAK1
PDGFRL
PKN1
PLEKHF2
PLP1
PPP2R5C
PRKACA
PRKCA
PRKCB
PRKCD
PRKCI
PRKCZ
PRKDC
PRMT1
PRMT5
PTAFR
PTPRA
RAF1
RAN
RPS6KA5
RTN4
SQSTM1
SRPK1
STK16
STK26
STK3
STK39
STK4
TBK1
TLK1
TLK2
TRAF6
TRPM7
TSSK6
ULK1
40 interacting genes:
AKT1
CASP3
CDK1
CNKSR1
CPNE1
DDAH2
EIF4EBP1
FAM9B
GAD1
GBP2
GMCL1
HSPE1
KEAP1
KHSRP
LATS1
LATS2
LRRK2
MARK2
MBP
MOB1B
MOB3B
MOB4
MPP1
ORM2
PEX19
PHAX
PLK1
QARS1
RAF1
RASSF1
RASSF2
RASSF4
SAV1
SLMAP
SNIP1
STK4
SULT2A1
TFPT
TRAF1
ZC3H7A
Entrez ID
4155
6788
HPRD ID
01158
05433
Ensembl ID
ENSG00000197971
ENSG00000104375
Uniprot IDs
A0A024R384
P02686
A0A087WZ06
A0A384MR07
Q13188
PDB IDs
1BX2
1FV1
1HQR
1K2D
1QCL
1YMM
1ZGL
3WWS
4HKD
4L0N
4LG4
4LGD
4OH9
5BRM
5DH3
6AO5
6AR2
Enriched GO Terms of Interacting Partners
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