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PRKCI and SQSTM1
Data Source:
HPRD
(in vivo, in vitro, two hybrid)
PRKCI
SQSTM1
Description
protein kinase C iota
sequestosome 1
Image
GO Annotations
Cellular Component
Golgi Membrane
Nucleus
Nucleoplasm
Endosome
Cytosol
Plasma Membrane
Bicellular Tight Junction
Microtubule Cytoskeleton
Apical Plasma Membrane
Cell Leading Edge
Schmidt-Lanterman Incisure
Intercellular Bridge
Extracellular Exosome
Schaffer Collateral - CA1 Synapse
Glutamatergic Synapse
Phagophore Assembly Site
P-body
Nucleoplasm
Cytoplasm
Mitochondrion
Late Endosome
Autophagosome
Endoplasmic Reticulum
Cytosol
Inclusion Body
Aggresome
PML Body
Sarcomere
Intracellular Membrane-bounded Organelle
Amphisome
Autolysosome
Extracellular Exosome
Sperm Midpiece
Lewy Body
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Kinase C Activity
Calcium-dependent Protein Kinase C Activity
Protein Binding
ATP Binding
Phospholipid Binding
Metal Ion Binding
Protein Serine/threonine Kinase Activity
Protein Kinase C Binding
Protein Binding
Zinc Ion Binding
Enzyme Binding
Protein Kinase Binding
Receptor Tyrosine Kinase Binding
Ubiquitin Protein Ligase Binding
Ionotropic Glutamate Receptor Binding
SH2 Domain Binding
Identical Protein Binding
Ubiquitin Binding
Protein-containing Complex Binding
K63-linked Polyubiquitin Modification-dependent Protein Binding
Biological Process
Protein Phosphorylation
Protein Targeting To Membrane
Cytoskeleton Organization
Actin Filament Organization
Positive Regulation Of Neuron Projection Development
Vesicle-mediated Transport
Cell Migration
Peptidyl-serine Phosphorylation
Cellular Response To Insulin Stimulus
Negative Regulation Of Glial Cell Apoptotic Process
Establishment Of Apical/basal Cell Polarity
Intracellular Signal Transduction
Eye Photoreceptor Cell Development
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity
Cell-cell Junction Organization
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Glucose Import
Secretion
Golgi Vesicle Budding
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Glial Cell Proliferation
Membrane Organization
Response To Interleukin-1
Bicellular Tight Junction Assembly
Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Endothelial Cell Apoptotic Process
Negative Regulation Of Transcription By RNA Polymerase II
Autophagy Of Mitochondrion
Mitophagy
Positive Regulation Of Protein Phosphorylation
Immune System Process
Response To Ischemia
Protein Phosphorylation
Ubiquitin-dependent Protein Catabolic Process
Autophagy
Apoptotic Process
Endosome Organization
Protein Localization
Regulation Of Mitochondrion Organization
Endosomal Transport
Macroautophagy
Cell Differentiation
Negative Regulation Of Protein Ubiquitination
Intracellular Signal Transduction
Aggrephagy
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Ras Protein Signal Transduction
Regulation Of Protein Complex Stability
Selective Autophagy
Interleukin-1-mediated Signaling Pathway
Response To Mitochondrial Depolarisation
Positive Regulation Of Long-term Synaptic Potentiation
Positive Regulation Of Protein Localization To Plasma Membrane
Protein Localization To Perinuclear Region Of Cytoplasm
Pathways
Pre-NOTCH Transcription and Translation
p75NTR recruits signalling complexes
Tight junction interactions
NRIF signals cell death from the nucleus
p75NTR recruits signalling complexes
NF-kB is activated and signals survival
PINK1-PRKN Mediated Mitophagy
Interleukin-1 signaling
Pexophagy
Drugs
Tamoxifen
Bisindolylmaleimide I
Fostamatinib
Diseases
Paget's disease of bone and related disorders, including: ; Paget's disease of bone (PDB); Familial expansile osteolysis (FEO); Early-onset Paget's disease of bone (PDB2); Expansile skeletal hyperphosphatasia (ESH); Juvenile Paget's disease (JPD)
GWAS
Microalbuminuria (
31511532
)
Prostate cancer (
25939597
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
31511532
)
Alzheimer's disease (late onset) (
24162737
)
Monocyte percentage of white cells (
32888494
)
Neutrophil percentage of white cells (
32888494
)
Interacting Genes
52 interacting genes:
ADAP1
ANXA1
APP
BAD
CASK
CASP8
CCNT1
CDC42
CDK7
CHUK
CTBP1
FABP4
FCGR3A
FRS2
FRS3
GAPDH
HRAS
IKBKG
IL1RAP
IRAK1
MAP2K1
MAP2K5
MAPT
MARK4
MBP
MEOX2
NACC1
NFKBIA
PARD3
PARD6A
PARD6B
PARD6G
PCM1
PDPK1
PNMA1
RAB2A
RAB4A
RAC1
RBM14
RHOQ
RPA2
SMG1
SMURF1
SQSTM1
SRC
TSC22D1
TTR
UBC
USP20
VHL
YWHAH
YWHAZ
106 interacting genes:
ATXN3
BCL2
BMPR1B
BPTF
BRCA1
CALCR
CALM1
CALR
CAMK2A
CCNB1
CDC37
CDC6
CDK1
CRBN
CRYAB
CSNK1A1
CSNK2A1
DAXX
DAZAP2
DNAI1
DNAI2
DNAJC10
EEF1D
FKBP4
GABARAP
GABARAPL1
GABARAPL2
GABRR1
GABRR2
GEMIN4
GRB14
GRIA1
GRIA2
GRIA3
HSPA5
HSPB1
IKBKB
IRAK1
ISG15
KAT5
KCNAB2
KEAP1
LCK
LINC01554
LRRK2
MALT1
MAP1LC3A
MAP1LC3B
MAP2K5
MAPK13
MAPK14
MAPT
MBP
MEIS2
MLH1
MTDH
NBR1
NCOR1
NR2F2
NTRK1
NTRK2
NTRK3
PADI1
PAWR
PIK3CA
PIK3R1
PPHLN1
PRKCD
PRKCI
PRKCZ
RAD23A
RAD54L2
RELN
RIPK1
RNF166
RNF168
RPL37
SKP2
SMAD1
SMAD2
SMAD3
SMAD4
SMURF1
SNCA
STXBP1
TBK1
TGFBR1
TKT
TOE1
TP53INP1
TRAF6
TRIB3
TRIM21
TRIM55
TRIM63
TTN
UBA52
UBB
UBC
UBE2D2
UBE2D3
ULK2
VANGL2
WDR81
XIAP
YWHAZ
Entrez ID
5584
8878
HPRD ID
02105
03319
Ensembl ID
ENSG00000163558
ENSG00000161011
Uniprot IDs
P41743
Q13501
PDB IDs
1VD2
1WMH
1ZRZ
3A8W
3A8X
3ZH8
5LI1
5LI9
5LIH
6ILZ
1Q02
2JY7
2JY8
2K0B
2KNV
4MJS
4UF8
4UF9
5YP7
5YP8
5YPA
5YPB
5YPC
5YPE
5YPF
5YPG
5YPH
6JM4
6KHZ
6MJ7
6TGY
6TH3
Enriched GO Terms of Interacting Partners
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