PRKCI and SMG1

Data Source:
HPRD (two hybrid, in vitro)

		PRKCI	SMG1
Description		protein kinase C iota	SMG1 nonsense mediated mRNA decay associated PI3K related kinase
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Endosome Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Apical Plasma Membrane Cell Leading Edge Schmidt-Lanterman Incisure Intercellular Bridge Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol TORC1 Complex TORC2 Complex
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Kinase C Activity Calcium-dependent Protein Kinase C Activity Protein Binding ATP Binding Phospholipid Binding Metal Ion Binding	RNA Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Telomeric DNA Binding Metal Ion Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Protein Phosphorylation Protein Targeting To Membrane Cytoskeleton Organization Actin Filament Organization Positive Regulation Of Neuron Projection Development Vesicle-mediated Transport Cell Migration Peptidyl-serine Phosphorylation Cellular Response To Insulin Stimulus Negative Regulation Of Glial Cell Apoptotic Process Establishment Of Apical/basal Cell Polarity Intracellular Signal Transduction Eye Photoreceptor Cell Development Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell-cell Junction Organization Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Glucose Import Secretion Golgi Vesicle Budding Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Glial Cell Proliferation Membrane Organization Response To Interleukin-1 Bicellular Tight Junction Assembly Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Endothelial Cell Apoptotic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay DNA Repair MRNA Export From Nucleus Negative Regulation Of Macroautophagy Peptidyl-serine Phosphorylation Regulation Of Telomere Maintenance TORC1 Signaling Protein Autophosphorylation Phosphatidylinositol Phosphorylation Regulation Of Response To DNA Damage Stimulus
Pathways		Pre-NOTCH Transcription and Translation p75NTR recruits signalling complexes Tight junction interactions	Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Tamoxifen Bisindolylmaleimide I Fostamatinib
Diseases
GWAS		Microalbuminuria ( 31511532) Prostate cancer ( 25939597) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Health literacy ( 31250787) Heel bone mineral density ( 30598549) Refractive error ( 32231278)
Interacting Genes		52 interacting genes: ADAP1 ANXA1 APP BAD CASK CASP8 CCNT1 CDC42 CDK7 CHUK CTBP1 FABP4 FCGR3A FRS2 FRS3 GAPDH HRAS IKBKG IL1RAP IRAK1 MAP2K1 MAP2K5 MAPT MARK4 MBP MEOX2 NACC1 NFKBIA PARD3 PARD6A PARD6B PARD6G PCM1 PDPK1 PNMA1 RAB2A RAB4A RAC1 RBM14 RHOQ RPA2 SMG1 SMURF1 SQSTM1 SRC TSC22D1 TTR UBC USP20 VHL YWHAH YWHAZ	9 interacting genes: CDH5 PRKCI SMAD9 SMG5 SMG8 SNAPIN UPF1 UPF2 UPF3A
Entrez ID		5584	23049
HPRD ID		02105	06123
Ensembl ID		ENSG00000163558	ENSG00000157106
Uniprot IDs		P41743	Q96Q15
PDB IDs		1VD2 1WMH 1ZRZ 3A8W 3A8X 3ZH8 5LI1 5LI9 5LIH 6ILZ	6L53 6L54 6SYT 6Z3R
Enriched GO Terms of Interacting Partners?
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