SH2D1A and DOK1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		SH2D1A	DOK1
Description		SH2 domain containing 1A	docking protein 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleus Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Height ( 31562340)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1
Entrez ID		4068	1796
HPRD ID		02390	04228
Ensembl ID		ENSG00000183918	ENSG00000115325
Uniprot IDs		O60880	B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27	2V76
Enriched GO Terms of Interacting Partners?
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