SH2D1A and LY9

Data Source:
HPRD (in vitro, in vivo)

		SH2D1A	LY9
Description		SH2 domain containing 1A	lymphocyte antigen 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Plasma Membrane Cell Surface Integral Component Of Membrane
	Molecular Function	Protein Binding	Molecular_function
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway	Cell Adhesion Positive Regulation Of Interleukin-17 Production Innate Immune Response T-helper 17 Cell Lineage Commitment
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS			Blood protein levels ( 29875488 28240269) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Monocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	3 interacting genes: AP2M1 SH2D1A SH2D1B
Entrez ID		4068	4063
HPRD ID		02390	02817
Ensembl ID		ENSG00000183918	ENSG00000122224
Uniprot IDs		O60880	A0A0C4DFU4 Q05CA2 Q0VAI0 Q5VYH9 Q9HBG7
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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