SH2D1A and LETMD1

Data Source:
BioGRID (two hybrid)

		SH2D1A	LETMD1
Description		SH2 domain containing 1A	LETM1 domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol	Nucleoplasm Nucleolus Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding Ribosome Binding
	Biological Process	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases		Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		32 interacting genes: AR ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB2 ERBB3 ERBB4 FYB1 FYN GRB2 KIT LCK LETMD1 LHX3 LHX4 LY9 MAPK11 MAPK14 MET NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1	10 interacting genes: APOC1 APOC2 APOC4 APP CCR1 FBXO7 HCK RHBDD2 SH2D1A TMEM167B
Entrez ID		4068	25875
HPRD ID		02390	09978
Ensembl ID		ENSG00000183918	ENSG00000050426
Uniprot IDs		O60880	A0A384P5D7 F8W1Z2 Q6P1Q0
PDB IDs		1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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