DOK1 and ABL2

Data Source:
BioGRID (unspecified method)

		DOK1	ABL2
Description		docking protein 1	ABL proto-oncogene 2, non-receptor tyrosine kinase
Image
GO Annotations	Cellular Component	Nucleus Cytosol Perinuclear Region Of Cytoplasm	Cytosol Actin Cytoskeleton
	Molecular Function	Protein Binding	Magnesium Ion Binding Phosphotyrosine Residue Binding Actin Monomer Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Manganese Ion Binding Actin Filament Binding
	Biological Process	Signal Transduction Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Axon Guidance Macrophage Colony-stimulating Factor Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway	Cellular Protein Modification Process Cell Adhesion Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Autophagy Positive Regulation Of Phospholipase C Activity Positive Regulation Of Neuron Projection Development Peptidyl-tyrosine Phosphorylation Regulation Of Endocytosis Regulation Of Cell Adhesion Negative Regulation Of Rho Protein Signal Transduction Exploration Behavior Positive Regulation Of Oxidoreductase Activity Cellular Response To Retinoic Acid Regulation Of Cell Motility Regulation Of Actin Cytoskeleton Reorganization
Pathways		PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling	Role of ABL in ROBO-SLIT signaling Role of ABL in ROBO-SLIT signaling Negative regulation of FLT3
Drugs			ATP Dasatinib XL228 K-00546 Fostamatinib
Diseases
GWAS		Height ( 31562340)	IgE grass sensitization ( 22036096)
Interacting Genes		41 interacting genes: ABL1 ABL2 BCR CRK CRKL CSK DOK3 ERBB2 FES FGR FYN GRB10 HCK INPP5D INSR ITGB1 ITGB2 ITGB3 ITGB5 ITGB7 ITK KIT LCK LYN MAP4K4 NCK1 NCK2 PIK3R1 PLCG1 PTK6 PTPN6 PTPRH RASA1 RET SH2D1A SHC1 SRC TEC TLN1 VAV1 YES1	34 interacting genes: ABI2 ABL1 AR BCR C15orf48 CAT CRK DOK1 EGFR EPHB2 ERBB2 ERBB3 ERBB4 FBXO38 GPX1 GRB2 HCK KIT MAP3K10 MDM2 MET NEDD4 NEDD4L OIP5 PDGFRB PIK3R3 PSMA7 RIN1 SIVA1 SORBS2 STAT3 TPD52L1 TRIP10 ZMAT1
Entrez ID		1796	27
HPRD ID		04228	01259
Ensembl ID		ENSG00000115325	ENSG00000143322
Uniprot IDs		B3KP83 B4DJN1 Q14CB2 Q2TA81 Q99704	P42684
PDB IDs		2V76	2ECD 2KK1 2XYN 3GVU 3HMI 3ULR 4EIH 5NP3 5NP5
Enriched GO Terms of Interacting Partners?
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