EIF6 and AKT1S1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	AKT1S1
Description		eukaryotic translation initiation factor 6	AKT1 substrate 1
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GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome	Nucleoplasm Cytoplasm Cytosol TORC1 Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	Protein Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway Regulation Of Cellular Response To Heat
Pathways			MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer
Drugs		Copper
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ
Entrez ID		3692	84335
HPRD ID		04221	12441
Ensembl ID		ENSG00000242372	ENSG00000204673
Uniprot IDs		P56537	A0A024QZF6 Q96B36
PDB IDs		6LQM 6LSR 6LSS 6LU8	5WBL 5WBU 5WBY 6SB0
Enriched GO Terms of Interacting Partners?
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