EIF6 and CRELD1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	CRELD1
Description		eukaryotic translation initiation factor 6	cysteine rich with EGF like domains 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome	Integral Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	Protein Disulfide Isomerase Activity Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Endocardial Cushion Development Cardiac Septum Development Protein Phosphopantetheinylation
Pathways
Drugs		Copper
Diseases			Atrioventricular septal defect; Atrioventricular canal defect
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Blood protein levels ( 30072576 29875488)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	14 interacting genes: ATP5MF COPS6 DRD2 EEF1G EIF6 GDF9 HTR2C KAT5 MAP3K1 MTNR1B POLA2 PTN SETDB1 ZNF408
Entrez ID		3692	78987
HPRD ID		04221	06206
Ensembl ID		ENSG00000242372	ENSG00000163703
Uniprot IDs		P56537	A0A024R2G1 Q96HD1
PDB IDs		6LQM 6LSR 6LSS 6LU8
Enriched GO Terms of Interacting Partners?
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