EIF6 and UPF3B

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	UPF3B
Description		eukaryotic translation initiation factor 6	UPF3B regulator of nonsense mediated mRNA decay
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GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Centriolar Satellite Exon-exon Junction Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	RNA Binding MRNA Binding Protein Binding Structural Constituent Of Nuclear Pore
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing Positive Regulation Of Translation
Pathways			Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Copper
Diseases			Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	13 interacting genes: EIF4A3 EIF6 EXOSC4 HBB MAGOH MCRS1 RBBP6 RBM8A SRPK2 TTC19 UPF1 UPF2 XRN1
Entrez ID		3692	65109
HPRD ID		04221	02247
Ensembl ID		ENSG00000242372	ENSG00000125351
Uniprot IDs		P56537	Q9BZI7
PDB IDs		6LQM 6LSR 6LSS 6LU8	1UW4 2XB2
Enriched GO Terms of Interacting Partners?
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