EIF6 and PDHA1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	PDHA1
Description		eukaryotic translation initiation factor 6	pyruvate dehydrogenase E1 subunit alpha 1
Image
GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome	Nucleus Nucleolus Mitochondrion Mitochondrial Matrix Mitochondrial Pyruvate Dehydrogenase Complex Pyruvate Dehydrogenase Complex
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	Pyruvate Dehydrogenase (acetyl-transferring) Activity Protein Binding Pyruvate Dehydrogenase (NAD+) Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Glucose Metabolic Process Acetyl-CoA Biosynthetic Process From Pyruvate Pyruvate Metabolic Process Tricarboxylic Acid Cycle Mitochondrial Acetyl-CoA Biosynthetic Process From Pyruvate
Pathways			Regulation of pyruvate dehydrogenase (PDH) complex Glyoxylate metabolism and glycine degradation Signaling by Retinoic Acid Pyruvate metabolism
Drugs		Copper	NADH
Diseases			Pyruvate dehydrogenase complex deficiency; X-linked Leigh syndrome
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Metabolite levels ( 23823483)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	9 interacting genes: DLAT EIF6 HSD17B10 PDHB PDK1 PDK2 PDK3 PDK4 PDP1
Entrez ID		3692	5160
HPRD ID		04221	02420
Ensembl ID		ENSG00000242372	ENSG00000131828
Uniprot IDs		P56537	A0A024RBX9 P08559
PDB IDs		6LQM 6LSR 6LSS 6LU8	1NI4 2OZL 3EXE 3EXF 3EXG 3EXH 3EXI 6CER 6CFO
Enriched GO Terms of Interacting Partners?
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