EIF6 and ABCF1

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		EIF6	ABCF1
Description		eukaryotic translation initiation factor 6	ATP binding cassette subfamily F member 1
Image
GO Annotations	Cellular Component	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome	Nuclear Envelope Nucleoplasm Cytosol Membrane
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding	RNA Binding Protein Binding ATP Binding Translation Factor Activity, RNA Binding ATPase Activity
	Biological Process	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process	Translation Inflammatory Response Transmembrane Transport
Pathways			ABC-family proteins mediated transport
Drugs		Copper
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Fish- and plant-related diet ( 32066663) Height ( 18391951) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Immature fraction of reticulocytes ( 32888494) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) General cognitive ability ( 29844566) IgM levels ( 28628107) Mild influenza (H1N1) infection ( 26379185)
Interacting Genes		41 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MEOX2 MRPS31 MSRB3 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 PTEN RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 VAC14 WFS1 XRN2 ZBTB26	4 interacting genes: APP EIF6 SUMO2 UBA1
Entrez ID		3692	23
HPRD ID		04221	09139
Ensembl ID		ENSG00000242372	ENSG00000204574
Uniprot IDs		P56537	A0A1U9X609 Q2L6I2 Q8NE71
PDB IDs		6LQM 6LSR 6LSS 6LU8	5ZXD
Enriched GO Terms of Interacting Partners?
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