PARVB and ARHGEF6

Data Source:
HPRD (two hybrid, in vitro)

		PARVB	ARHGEF6
Description		parvin beta	Rac/Cdc42 guanine nucleotide exchange factor 6
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium	Cytosol Lamellipodium
	Molecular Function	Actin Binding Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Establishment Or Maintenance Of Cell Polarity Cell Projection Assembly Lamellipodium Assembly Actin Cytoskeleton Reorganization Substrate Adhesion-dependent Cell Spreading Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape	Apoptotic Process G Protein-coupled Receptor Signaling Pathway JNK Cascade Lamellipodium Assembly Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42
Drugs
Diseases			Non-syndromic X-linked mental retardation
GWAS		Alzheimer's disease (cognitive decline) ( 23535033) Hematological and biochemical traits ( 20139978) Lewy body disease ( 25188341) Nonalcoholic fatty liver disease ( 22719876) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Response to chemotherapy in breast cancer (hypertension) (bevacizumab) ( 25117820) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Systemic sclerosis (anti-centromere-positive) ( 29293537)	Breast cancer ( 29059683)
Interacting Genes		2 interacting genes: ARHGEF6 ILK	37 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		29780	9459
HPRD ID		16284	02226
Ensembl ID		ENSG00000188677	ENSG00000129675
Uniprot IDs		A0A087WZB5 Q9HBI1	B7Z3C7 Q15052 Q8N4Q3
PDB IDs		4EDL 4EDM 4EDN	1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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