LCE1B and TGM1

Data Source:
BioGRID (two hybrid)

		LCE1B	TGM1
Description		late cornified envelope 1B	transglutaminase 1
Image		No pdb structure
GO Annotations	Cellular Component		Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Keratinization	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification
Pathways		Formation of the cornified envelope	Formation of the cornified envelope
Drugs
Diseases			Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS		Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)
Interacting Genes		72 interacting genes: ADAMTSL4 BEND5 CYSRT1 FBLN1 FUCA2 HOXA1 KRT31 KRTAP1-3 KRTAP1-5 KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP12-3 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP3-1 KRTAP3-2 KRTAP4-1 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP4-4 KRTAP4-5 KRTAP5-11 KRTAP5-2 KRTAP5-3 KRTAP5-4 KRTAP5-6 KRTAP5-7 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-4 KRTAP9-8 LCE1A LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3B LCE3C LCE4A LCE5A MDFI MEOX2 NAPSA NBPF19 NOTCH2NLA NUFIP2 OTX1 P4HB RGS17 RGS20 RNF4 SMCP SPRY1 SPRY2 SPRY3 TGM1 TRIM42	34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4
Entrez ID		353132	7051
HPRD ID		17259	01824
Ensembl ID		ENSG00000196734	ENSG00000092295
Uniprot IDs		Q5T7P3	P22735
PDB IDs			2XZZ
Enriched GO Terms of Interacting Partners?
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