TGM1 and PLAAT4

Data Source:
HPRD (in vitro)

		TGM1	PLAAT4
Description		transglutaminase 1	phospholipase A and acyltransferase 4
Image
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Intrinsic Component Of Membrane Extracellular Exosome	Cytoplasm Cytosol Membrane Integral Component Of Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Identical Protein Binding Metal Ion Binding	Phospholipase A2 Activity Protein Binding Phospholipase A1 Activity N-acyltransferase Activity Phosphatidylserine 1-acylhydrolase Activity 1-acyl-2-lysophosphatidylserine Acylhydrolase Activity Phospholipase A2 Activity (consuming 1,2-dipalmitoylphosphatidylcholine) Phospholipase A2 Activity Consuming 1,2-dioleoylphosphatidylethanolamine)
	Biological Process	Cellular Protein Modification Process Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Protein Phosphopantetheinylation Keratinocyte Differentiation Cell Envelope Organization Positive Regulation Of Cell Cycle Cornification	Phospholipid Metabolic Process Negative Regulation Of Cell Population Proliferation Lipid Catabolic Process Phosphatidylethanolamine Acyl-chain Remodeling Positive Regulation Of Keratinocyte Differentiation N-acylphosphatidylethanolamine Metabolic Process Positive Regulation Of Protein-glutamine Gamma-glutamyltransferase Activity
Pathways		Formation of the cornified envelope	Acyl chain remodelling of PE
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	6 interacting genes: HRAS PIK3R3 SGTA TGM1 TRIM25 UBE2I
Entrez ID		7051	5920
HPRD ID		01824	05479
Ensembl ID		ENSG00000092295	ENSG00000133321
Uniprot IDs		P22735	Q9UL19
PDB IDs		2XZZ	2LKT 2MY9
Enriched GO Terms of Interacting Partners?
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