APOC3 and ARFGAP1

Data Source:
BioGRID (two hybrid)

		APOC3	ARFGAP1
Description		apolipoprotein C3	ADP ribosylation factor GTPase activating protein 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Early Endosome Very-low-density Lipoprotein Particle Intermediate-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Chylomicron Collagen-containing Extracellular Matrix Extracellular Exosome	Golgi Membrane Cytosol Synapse
	Molecular Function	Protein Binding Phospholipid Binding Cholesterol Binding Enzyme Regulator Activity Lipase Inhibitor Activity High-density Lipoprotein Particle Receptor Binding	GTPase Activator Activity Protein Binding Metal Ion Binding
	Biological Process	Retinoid Metabolic Process Triglyceride Metabolic Process G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Triglyceride Catabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Negative Regulation Of Very-low-density Lipoprotein Particle Clearance Negative Regulation Of High-density Lipoprotein Particle Clearance Negative Regulation Of Low-density Lipoprotein Particle Clearance Triglyceride Catabolic Process Regulation Of Cdc42 Protein Signal Transduction Cholesterol Efflux Phospholipid Efflux Chylomicron Remodeling High-density Lipoprotein Particle Remodeling Chylomicron Assembly Very-low-density Lipoprotein Particle Assembly Chylomicron Remnant Clearance Lipoprotein Metabolic Process Cholesterol Homeostasis Reverse Cholesterol Transport Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Lipid Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Negative Regulation Of Lipid Catabolic Process Negative Regulation Of Lipoprotein Lipase Activity Negative Regulation Of Cholesterol Import Triglyceride Homeostasis	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Regulation Of Endocytosis Regulation Of ARF Protein Signal Transduction IRE1-mediated Unfolded Protein Response Positive Regulation Of GTPase Activity
Pathways		Chylomicron assembly Chylomicron remodeling HDL remodeling Retinoid metabolism and transport Retinoid metabolism and transport	XBP1(S) activates chaperone genes COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic Clathrin-mediated endocytosis
Drugs		Copper Volanesorsen
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 31978080) Cholesterol, total ( 19060911 20686565) Coronary heart disease ( 21378990) Delirium ( 29631748) Fasting triglyceride levels ( 32603185) HDL cholesterol ( 28270201 20864672 19060906 30275531 20686565 26582766) HDL cholesterol levels ( 28334899) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 28548082) Hypertriglyceridemia ( 23505323) LDL cholesterol ( 18179892 20864672 19060911 20686565) LDL cholesterol levels ( 28334899) Lipid metabolism phenotypes ( 22286219) Lipid traits ( 30576415 24386095) Lipoprotein (a) - cholesterol levels ( 25575512) Metabolite levels ( 22916037) Platelet count ( 27863252) Plateletcrit ( 32888494 27863252) Postprandial triglyceride levels ( 32603185) Red cell distribution width ( 32888494) Refractive error ( 32231278) Total cholesterol levels ( 28334899) Triglyceride levels ( 28334899 26763881 28371326 28548082) Triglycerides ( 19074352 21909109 18193043 18193044 20864672 19060906 19060911 20139978 20686565 26582766)
Interacting Genes		6 interacting genes: ARFGAP1 ERGIC3 FAM209A GPX8 SOX4 VKORC1	34 interacting genes: AGTR1 APOB APOC3 APOE APP ARF1 ASB10 COPA COPS5 CSNK1D CYTH2 FOS GABARAPL2 GRN HRAS KDELR1 KRTAP10-9 KRTAP3-2 KRTAP9-2 LRRK2 MAP1LC3B MED27 PRKACB RAB23 RABGAP1L RASIP1 REEP5 RFC3 RGS2 RPL11 SMN1 TK1 TMED2 TRIM23
Entrez ID		345	55738
HPRD ID		00132	06443
Ensembl ID		ENSG00000110245	ENSG00000101199
Uniprot IDs		A3KPE2 P02656	Q53F62 Q8N6T3
PDB IDs		2JQ3	3DWD 3O47
Enriched GO Terms of Interacting Partners?
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