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HUS1 and OGG1
Data Source:
BioGRID
(affinity chromatography technology, pull down)
HUS1
OGG1
Description
HUS1 checkpoint clamp component
8-oxoguanine DNA glycosylase
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Checkpoint Clamp Complex
Site Of Double-strand Break
Nucleus
Nucleoplasm
Mitochondrion
Nuclear Matrix
Nuclear Speck
Protein-containing Complex
Molecular Function
Protein Binding
Damaged DNA Binding
Endonuclease Activity
Protein Binding
Microtubule Binding
Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity
Oxidized Purine DNA Binding
8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity
Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Regulation Of Protein Phosphorylation
DNA Replication
DNA Repair
Nucleotide-excision Repair
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To UV
Embryo Development Ending In Birth Or Egg Hatching
Intra-S DNA Damage Checkpoint
Mitotic DNA Replication Checkpoint
Meiotic DNA Integrity Checkpoint
Cellular Response To Ionizing Radiation
Regulation Of Signal Transduction By P53 Class Mediator
Acute Inflammatory Response
Base-excision Repair
Base-excision Repair, AP Site Formation
Regulation Of Transcription, DNA-templated
Cellular Response To DNA Damage Stimulus
Response To Oxidative Stress
Aging
Response To Radiation
Response To Light Stimulus
Response To Estradiol
Nucleotide-excision Repair, DNA Incision
Response To Drug
Negative Regulation Of Apoptotic Process
Depurination
Depyrimidination
Response To Ethanol
Response To Folic Acid
Cellular Response To Cadmium Ion
Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
Recognition and association of DNA glycosylase with site containing an affected pyrimidine
Cleavage of the damaged pyrimidine
Recognition and association of DNA glycosylase with site containing an affected purine
Cleavage of the damaged purine
Displacement of DNA glycosylase by APEX1
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Defective OGG1 Substrate Binding
Defective OGG1 Substrate Processing
Drugs
Diseases
GWAS
Gut microbiota alpha diversity (Shannon index) (
33208821
)
Obstructive sleep apnea during REM sleep (apnea hypopnea index) (
29077507
)
Interacting Genes
28 interacting genes:
C4orf46
CD200
DCUN1D5
DNAJC7
FEN1
GRIP1
HDAC1
HUS1B
MSH2
MSH3
MSH6
NEIL1
NTAQ1
OGG1
PCNA
POLB
RAD1
RAD17
RAD9A
RAD9B
RHNO1
RPA1
RPA2
SDCBP
SIRT6
TDG
TOPBP1
YWHAQ
6 interacting genes:
CHGB
HUS1
PRKCA
RAD1
RAD9A
XRCC1
Entrez ID
3364
4968
HPRD ID
04787
03582
Ensembl ID
ENSG00000136273
ENSG00000114026
Uniprot IDs
A4D2F2
O60921
E5KPM5
E5KPM6
E5KPM7
E5KPM8
E5KPM9
E5KPN0
E5KPN1
O15527
PDB IDs
3A1J
3G65
3GGR
6J8Y
1EBM
1FN7
1HU0
1KO9
1LWV
1LWW
1LWY
1M3H
1M3Q
1N39
1N3A
1N3C
1YQK
1YQL
1YQM
1YQR
2I5W
2NOB
2NOE
2NOF
2NOH
2NOI
2NOL
2NOZ
2XHI
3IH7
3KTU
5AN4
6RLW
6W0M
6W0R
6W13
Enriched GO Terms of Interacting Partners
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Tagcloud (Difference)
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Tagcloud (Intersection)
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