HUS1 and TOPBP1

Data Source:
BioGRID (pull down)

		HUS1	TOPBP1
Description		HUS1 checkpoint clamp component	DNA topoisomerase II binding protein 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Checkpoint Clamp Complex Site Of Double-strand Break	Condensed Nuclear Chromosome Spindle Pole Male Germ Cell Nucleus Nucleus Nucleoplasm Chromosome Cytoplasm Microtubule Organizing Center Plasma Membrane Actin Cytoskeleton Nuclear Body PML Body Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding	DNA Binding Protein Binding Protein C-terminus Binding Identical Protein Binding
	Biological Process	DNA Damage Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Regulation Of Protein Phosphorylation DNA Replication DNA Repair Nucleotide-excision Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Response To UV Embryo Development Ending In Birth Or Egg Hatching Intra-S DNA Damage Checkpoint Mitotic DNA Replication Checkpoint Meiotic DNA Integrity Checkpoint Cellular Response To Ionizing Radiation Regulation Of Signal Transduction By P53 Class Mediator	DNA Metabolic Process DNA Replication DNA Replication Initiation DNA Repair Cellular Response To DNA Damage Stimulus Mitotic G2 DNA Damage Checkpoint Response To Ionizing Radiation Mitotic DNA Replication Checkpoint Regulation Of Signal Transduction By P53 Class Mediator
Pathways		Activation of ATR in response to replication stress HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint	HDR through Single Strand Annealing (SSA) Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases
GWAS		Gut microbiota alpha diversity (Shannon index) ( 33208821) Obstructive sleep apnea during REM sleep (apnea hypopnea index) ( 29077507)	Iron status biomarkers ( 19084217)
Interacting Genes		28 interacting genes: C4orf46 CD200 DCUN1D5 DNAJC7 FEN1 GRIP1 HDAC1 HUS1B MSH2 MSH3 MSH6 NEIL1 NTAQ1 OGG1 PCNA POLB RAD1 RAD17 RAD9A RAD9B RHNO1 RPA1 RPA2 SDCBP SIRT6 TDG TOPBP1 YWHAQ	32 interacting genes: ABL1 AKT1 ATM BLM BMPR2 BRIP1 CDC45 CHEK1 CLSTN1 E2F1 ESR1 FHL3 GINS1 HUS1 PML POLE PPHLN1 PPP1CC RAD1 RAD9A RAI1 RBBP8 RHNO1 SF3B2 SMARCAD1 TBC1D4 TCFL5 TEX11 TICRR TOP2B UBR5 ZBTB17
Entrez ID		3364	11073
HPRD ID		04787	09678
Ensembl ID		ENSG00000136273	ENSG00000163781
Uniprot IDs		A4D2F2 O60921	A0AV47 A7E2X7 Q05BV8 Q92547
PDB IDs		3A1J 3G65 3GGR 6J8Y	1WF6 2XNH 2XNK 3AL2 3AL3 3JVE 3OLC 3PD7 3UEN 3UEO 6RML 6RMM
Enriched GO Terms of Interacting Partners?
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