OGG1 and XRCC1

Data Source:
BioGRID (pull down, two hybrid)
HPRD (in vitro, two hybrid)

		OGG1	XRCC1
Description		8-oxoguanine DNA glycosylase	X-ray repair cross complementing 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion Nuclear Matrix Nuclear Speck Protein-containing Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Nucleolus ERCC4-ERCC1 Complex
	Molecular Function	Damaged DNA Binding Endonuclease Activity Protein Binding Microtubule Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity Oxidized Purine DNA Binding 8-oxo-7,8-dihydroguanine DNA N-glycosylase Activity Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Protein Binding Enzyme Binding Oxidized DNA Binding 3' Overhang Single-stranded DNA Endodeoxyribonuclease Activity
	Biological Process	Acute Inflammatory Response Base-excision Repair Base-excision Repair, AP Site Formation Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Response To Oxidative Stress Aging Response To Radiation Response To Light Stimulus Response To Estradiol Nucleotide-excision Repair, DNA Incision Response To Drug Negative Regulation Of Apoptotic Process Depurination Depyrimidination Response To Ethanol Response To Folic Acid Cellular Response To Cadmium Ion Negative Regulation Of Double-strand Break Repair Via Single-strand Annealing	Single Strand Break Repair Double-strand Break Repair Via Homologous Recombination Response To Hypoxia Transcription-coupled Nucleotide-excision Repair Base-excision Repair Base-excision Repair, DNA Ligation Nucleotide-excision Repair, DNA Gap Filling Double-strand Break Repair Via Nonhomologous End Joining Response To Organic Substance Negative Regulation Of Protein ADP-ribosylation Cerebellum Morphogenesis Hippocampus Development Response To Hydroperoxide Response To Drug Voluntary Musculoskeletal Movement Telomeric DNA-containing Double Minutes Formation Positive Regulation Of Single Strand Break Repair Positive Regulation Of DNA Ligase Activity Negative Regulation Of Protection From Non-homologous End Joining At Telomere Replication-born Double-strand Break Repair Via Sister Chromatid Exchange
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Displacement of DNA glycosylase by APEX1 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway Defective OGG1 Substrate Binding Defective OGG1 Substrate Processing	Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS			Apolipoprotein B levels ( 32203549) Height ( 31562340) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Plasma amyloid beta peptide concentrations (ABx-42) ( 24535457)
Interacting Genes		6 interacting genes: CHGB HUS1 PRKCA RAD1 RAD9A XRCC1	18 interacting genes: APEX1 APLF APTX BRCA1 BTRC CSNK2A1 CSNK2A2 LIG3 NEIL1 OGG1 PARP1 PARP2 PCNA PNKP POLB RNF146 TOPORS UBE2I
Entrez ID		4968	7515
HPRD ID		03582	01909
Ensembl ID		ENSG00000114026	ENSG00000073050
Uniprot IDs		E5KPM5 E5KPM6 E5KPM7 E5KPM8 E5KPM9 E5KPN0 E5KPN1 O15527	B2RCY5 P18887 Q59HH7
PDB IDs		1EBM 1FN7 1HU0 1KO9 1LWV 1LWW 1LWY 1M3H 1M3Q 1N39 1N3A 1N3C 1YQK 1YQL 1YQM 1YQR 2I5W 2NOB 2NOE 2NOF 2NOH 2NOI 2NOL 2NOZ 2XHI 3IH7 3KTU 5AN4 6RLW 6W0M 6W0R 6W13	1CDZ 1XNA 1XNT 2D8M 2W3O 3K75 3K77 3LQC 5E6Q 5W7X 5W7Y
Enriched GO Terms of Interacting Partners?
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