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HUS1 and POLB
Data Source:
BioGRID
(pull down)
HUS1
POLB
Description
HUS1 checkpoint clamp component
DNA polymerase beta
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Nucleolus
Cytosol
Checkpoint Clamp Complex
Site Of Double-strand Break
Nucleus
Nucleoplasm
Cytoplasm
Microtubule
Spindle Microtubule
Protein-containing Complex
Molecular Function
Protein Binding
Damaged DNA Binding
DNA-directed DNA Polymerase Activity
DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
Protein Binding
Microtubule Binding
Lyase Activity
Enzyme Binding
Metal Ion Binding
Biological Process
DNA Damage Checkpoint
Telomere Maintenance
Double-strand Break Repair Via Homologous Recombination
Regulation Of Protein Phosphorylation
DNA Replication
DNA Repair
Nucleotide-excision Repair
Protein Phosphorylation
Cellular Response To DNA Damage Stimulus
Response To UV
Embryo Development Ending In Birth Or Egg Hatching
Intra-S DNA Damage Checkpoint
Mitotic DNA Replication Checkpoint
Meiotic DNA Integrity Checkpoint
Cellular Response To Ionizing Radiation
Regulation Of Signal Transduction By P53 Class Mediator
In Utero Embryonic Development
DNA-dependent DNA Replication
DNA Repair
Base-excision Repair
Base-excision Repair, Base-free Sugar-phosphate Removal
Base-excision Repair, Gap-filling
Base-excision Repair, DNA Ligation
Pyrimidine Dimer Repair
Nucleotide-excision Repair, DNA Gap Filling
Double-strand Break Repair Via Nonhomologous End Joining
Inflammatory Response
Cellular Response To DNA Damage Stimulus
Salivary Gland Morphogenesis
Aging
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Response To Gamma Radiation
Somatic Hypermutation Of Immunoglobulin Genes
Protein Deubiquitination
Response To Ethanol
Lymph Node Development
Spleen Development
Homeostasis Of Number Of Cells
Neuron Apoptotic Process
Response To Hyperoxia
Immunoglobulin Heavy Chain V-D-J Recombination
DNA Biosynthetic Process
Pathways
Activation of ATR in response to replication stress
HDR through Single Strand Annealing (SSA)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Regulation of TP53 Activity through Phosphorylation
G2/M DNA damage checkpoint
POLB-Dependent Long Patch Base Excision Repair
Resolution of AP sites via the multiple-nucleotide patch replacement pathway
Resolution of AP sites via the single-nucleotide replacement pathway
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
PCNA-Dependent Long Patch Base Excision Repair
Ub-specific processing proteases
Abasic sugar-phosphate removal via the single-nucleotide replacement pathway
Drugs
Cytarabine
Iron
dATP
(1S)-1,2,3,4-TETRAHYDRO-BENZO[C]PHENANTHRENE-2,3,4-TRIOL
Ferrous gluconate
Ferrous succinate
Ferrous ascorbate
Ferrous fumarate
Ferrous glycine sulfate
Diseases
GWAS
Gut microbiota alpha diversity (Shannon index) (
33208821
)
Obstructive sleep apnea during REM sleep (apnea hypopnea index) (
29077507
)
Plasma parathyroid hormone levels (
30134803
)
Plasma plasminogen activator levels (
24578379
)
Interacting Genes
28 interacting genes:
C4orf46
CD200
DCUN1D5
DNAJC7
FEN1
GRIP1
HDAC1
HUS1B
MSH2
MSH3
MSH6
NEIL1
NTAQ1
OGG1
PCNA
POLB
RAD1
RAD17
RAD9A
RAD9B
RHNO1
RPA1
RPA2
SDCBP
SIRT6
TDG
TOPBP1
YWHAQ
19 interacting genes:
APEX1
BRCA1
EP300
HUS1
HUWE1
KAT7
NEIL1
PCNA
PNKP
PRKCA
RAD1
RAD9A
SRPK2
STUB1
TAF1D
TLE1
TPP2
WRN
XRCC1
Entrez ID
3364
5423
HPRD ID
04787
07517
Ensembl ID
ENSG00000136273
ENSG00000070501
Uniprot IDs
A4D2F2
O60921
B7Z1W5
P06746
PDB IDs
3A1J
3G65
3GGR
6J8Y
1BPX
1BPY
1BPZ
1MQ2
1MQ3
1TV9
1TVA
1ZJM
1ZJN
1ZQA
1ZQB
1ZQC
1ZQD
1ZQE
1ZQF
1ZQG
1ZQH
1ZQI
1ZQJ
1ZQK
1ZQL
1ZQM
1ZQN
1ZQO
1ZQP
1ZQQ
1ZQR
1ZQS
1ZQT
2FMP
2FMQ
2FMS
2I9G
2ISO
2ISP
2P66
2PXI
3C2K
3C2L
3C2M
3GDX
3ISB
3ISC
3ISD
3JPN
3JPO
3JPP
3JPQ
3JPR
3JPS
3JPT
3LK9
3MBY
3OGU
3RH4
3RH5
3RH6
3RJE
3RJF
3RJG
3RJH
3RJI
3RJJ
3RJK
3TFR
3TFS
4DO9
4DOA
4DOB
4DOC
4F5N
4F5O
4F5P
4F5Q
4F5R
4GXI
4GXJ
4GXK
4JWM
4JWN
4KLD
4KLE
4KLF
4KLG
4KLH
4KLI
4KLJ
4KLL
4KLM
4KLO
4KLQ
4KLS
4KLT
4KLU
4LVS
4M2Y
4M47
4M9G
4M9H
4M9J
4M9L
4M9N
4MF2
4MF8
4MFA
4MFC
4MFF
4NLK
4NLN
4NLZ
4NM1
4NM2
4NXZ
4NY8
4O5C
4O5E
4O5K
4O9M
4P2H
4PGQ
4PGX
4PGY
4PH5
4PHA
4PHD
4PHE
4PHP
4PPX
4R63
4R64
4R65
4R66
4RPX
4RPY
4RPZ
4RQ0
4RQ1
4RQ2
4RQ3
4RQ4
4RQ5
4RQ6
4RQ7
4RQ8
4RT2
4RT3
4TUP
4TUQ
4TUR
4TUS
4UAW
4UAY
4UAZ
4UB1
4UB2
4UB3
4UB4
4UB5
4UBB
4UBC
4YMM
4YMN
4YMO
4YN4
4Z6C
4Z6D
4Z6E
4Z6F
5BOL
5BOM
5BPC
5DB6
5DB7
5DB8
5DB9
5DBA
5DBB
5DBC
5EOZ
5HHH
5HHI
5J0O
5J0P
5J0Q
5J0R
5J0S
5J0T
5J0U
5J0W
5J0X
5J0Y
5J29
5J2A
5J2B
5J2C
5J2D
5J2E
5J2F
5J2G
5J2H
5J2I
5J2J
5J2K
5TB8
5TB9
5TBA
5TBB
5TBC
5TZV
5U2R
5U2S
5U2T
5U8G
5U8H
5U8I
5U9H
5UGN
5UGO
5UGP
5V1F
5V1G
5V1H
5V1I
5V1J
5V1N
5V1O
5V1P
5V1R
5VEZ
5VRW
5VRX
5VRY
5VRZ
5VS0
5VS1
5VS2
5VS3
5VS4
5WNX
5WNY
5WNZ
5WO0
6BEL
6BEM
6BTE
6BTF
6CLY
6CPQ
6CR3
6CR4
6CR5
6CR6
6CR7
6CR8
6CR9
6CRB
6CRC
6CRH
6CTI
6CTJ
6CTK
6CTL
6CTM
6CTN
6CTO
6CTP
6CTQ
6CTR
6CTT
6CTU
6CTV
6CTW
6CTX
6CU9
6CUA
6CUB
6DIA
6DIC
6E3R
6E3V
6E3W
6E3X
6G2Q
6MR7
6MR8
6N2R
6N2S
6N2T
6NKR
6NKS
6NKT
6NKU
6NKV
6NKW
6NKX
6NKY
6NKZ
6NL0
6PH5
6PH6
6PKZ
6U2O
6U6B
6UOK
6UOL
6UOM
6W2M
7ICE
7ICF
7ICG
7ICH
7ICI
7ICJ
7ICK
7ICL
7ICM
7ICN
7ICO
7ICP
7ICQ
7ICR
7ICS
7ICT
7ICU
7ICV
8ICA
8ICB
8ICC
8ICE
8ICF
8ICG
8ICH
8ICI
8ICJ
8ICK
8ICL
8ICM
8ICN
8ICO
8ICP
8ICQ
8ICR
8ICS
8ICT
8ICU
8ICV
8ICW
8ICX
8ICY
8ICZ
9ICA
9ICB
9ICC
9ICE
9ICF
9ICG
9ICH
9ICI
9ICJ
9ICK
9ICL
9ICM
9ICN
9ICO
9ICP
9ICQ
9ICR
9ICS
9ICT
9ICU
9ICV
9ICW
9ICX
9ICY
Enriched GO Terms of Interacting Partners
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